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  • Evaluating the contribution of rare variants to type 2 diabetes and related traits using pedigrees 

    Jun G; Manning A; Almeida M; Zawistowski M; Wood AR; Teslovich TM; Fuchsberger C; Feng S; Cingolani P; Gaulton KJ; Dyer T; Blackwell TW; Chen H; Chines PS; Choi S; Churchhouse C; Fontanillas P; King R; Lee S; Lincoln SE; Trubetskoy V; DePristo M; Fingerlin T; Grossman R; Grundstad J; Heath A; Kim J; Kim YJ; Laramie J; Lee J; Li H; Liu X; Livne O; Locke AE; Maller J; Mazur A; Morris AP; Pollin TI; Ragona D; Reich D; Rivas MA; Scott LJ; Sim X; Tearle RG; Teo YY; Williams AL; Zöllner S; Curran JE; Peralta J; Akolkar B; Bell GI; Burtt NP; Cox NJ; Florez JC; Hanis CL; McKeon C; Mohlke KL; Seielstad M; Wilson JG; Atzmon G; Below JE; Dupuis J; Nicolae DL; Lehman D; Park T; Won S; Sladek R; Altshuler D; McCarthy MI; Duggirala R; Boehnke M; Frayling TM; Abecasis GR; Blangero J (2018)
    A major challenge in evaluating the contribution of rare variants to complex disease is identifying enough copies of the rare alleles to permit informative statistical analysis. To investigate the contribution of rare ...