Now showing items 1-20 of 21

    • Biological, clinical and population relevance of 95 loci for blood lipids 

      Teslovich TM; Musunuru K; Smith AV; Edmondson AC; Stylianou IM; Koseki M; Pirruccello JP; Ripatti S; Chasman DI; Willer CJ; Johansen CT; Fouchier SW; Isaacs A; Peloso GM; Barbalic M; Ricketts SL; Bis JC; Aulchenko YS; Thorleifsson G; Feitosa MF; Chambers J; Orho-Melander M; Melander O; Johnson T; Li X; Guo X; Li M; Shin Cho Y; Jin Go M; Jin Kim Y; Lee JY; Park T; Kim K; Sim X; Twee-Hee Ong R; Croteau-Chonka DC; Lange LA; Smith JD; Song K; Hua Zhao J; Yuan X; Luan J; Lamina C; Ziegler A; Zhang W; Zee RY; Wright AF; Witteman JC; Wilson JF; Willemsen G; Wichmann HE; Whitfield JB; Waterworth DM; Wareham NJ; Waeber G; Vollenweider P; Voight BF; Vitart V; Uitterlinden AG; Uda M; Tuomilehto J; Thompson JR; Tanaka T; Surakka I; Stringham HM; Spector TD; Soranzo N; Smit JH; Sinisalo J; Silander K; Sijbrands EJ; Scuteri A; Scott J; Schlessinger D; Sanna S; Salomaa V; Saharinen J; Sabatti C; Ruokonen A; Rudan I; Rose LM; Roberts R; Rieder M; Psaty BM; Pramstaller PP; Pichler I; Perola M; Penninx BW; Pedersen NL; Pattaro C; Parker AN; Pare G; Oostra BA; O'Donnell CJ; Nieminen MS; Nickerson DA; Montgomery GW; Meitinger T; McPherson R; McCarthy MI; McArdle W; Masson D; Martin NG; Marroni F; Mangino M; Magnusson PK; Lucas G; Luben R; Loos RJ; Lokki ML; Lettre G; Langenberg C; Launer LJ; Lakatta EG; Laaksonen R; Kyvik KO; Kronenberg F; König IR; Khaw KT; Kaprio J; Kaplan LM; Johansson A; Jarvelin MR; Janssens AC; Ingelsson E; Igl W; Kees Hovingh G; Hottenga JJ; Hofman A; Hicks AA; Hengstenberg C; Heid IM; Hayward C; Havulinna AS; Hastie ND; Harris TB; Haritunians T; Hall AS; Gyllensten U; Guiducci C; Groop LC; Gonzalez E; Gieger C; Freimer NB; Ferrucci L; Erdmann J; Elliott P; Ejebe KG; Döring A; Dominiczak AF; Demissie S; Deloukas P; de Geus EJ; de Faire U; Crawford G; Collins FS; Chen YD; Caulfield MJ; Campbell H; Burtt NP; Bonnycastle LL; Boomsma DI; Boekholdt SM; Bergman RN; Barroso I; Bandinelli S; Ballantyne CM; Assimes TL; Quertermous T; Altshuler D; Seielstad M; Wong TY; Tai ES; Feranil AB; Kuzawa CW; Adair LS; Taylor HA; Borecki IB; Gabriel SB; Wilson JG; Holm H; Thorsteinsdottir U; Gudnason V; Krauss RM; Mohlke KL; Ordovas JM; Munroe PB; Kooner JS; Tall AR; Hegele RA; Kastelein JJ; Schadt EE; Rotter JI; Boerwinkle E; Strachan DP; Mooser V; Stefansson K; Reilly MP; Samani NJ; Schunkert H; Cupples LA; Sandhu MS; Ridker PM; Rader DJ; van Duijn CM; Peltonen L; Abecasis GR; Boehnke M; Kathiresan S (2010)
      Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides are among the most important risk factors for coronary artery disease (CAD) and are ...
    • CUBN is a gene locus for albuminuria 

      Böger CA; Chen MH; Tin A; Olden M; Köttgen A; de Boer IH; Fuchsberger C; O'Seaghdha CM; Pattaro C; Teumer A; Liu CT; Glazer NL; Li M; O'Connell JR; Tanaka T; Peralta CA; Kutalik Z; Luan J; Zhao JH; Hwang SJ; Akylbekova E; Kramer H; van der Harst P; Smith AV; Lohman K; de Andrade M; Hayward C; Kollerits B; Tönjes A; Aspelund T; Ingelsson E; Eiriksdottir G; Launer LJ; Harris TB; Shuldiner AR; Mitchell BD; Arking DE; Franceschini N; Boerwinkle E; Egan J; Hernandez D; Reilly M; Townsend RR; Lumley T; Siscovick DS; Psaty BM; Kestenbaum B; Haritunians T; Bergmann S; Vollenweider P; Waeber G; Mooser V; Waterworth D; Johnson AD; Florez JC; Meigs JB; Lu X; Turner ST; Atkinson EJ; Leak TS; Aasarød K; Skorpen F; Syvänen AC; Illig T; Baumert J; Koenig W; Krämer BK; Devuyst O; Mychaleckyj JC; Minelli C; Bakker SJ; Kedenko L; Paulweber B; Coassin S; Endlich K; Kroemer HK; Biffar R; Stracke S; Völzke H; Stumvoll M; Mägi R; Campbell H; Vitart V; Hastie ND; Gudnason V; Kardia SL; Liu Y; Polasek O; Curhan G; Kronenberg F; Prokopenko I; Rudan I; Arnlöv J; Hallan S; Navis G; CKDGen Consortium; Parsa A; Ferrucci L; Coresh J; Shlipak MG; Bull SB; Paterson NJ; Wichmann HE; Wareham NJ; Loos RJ; Rotter JI; Pramstaller PP; Cupples LA; Beckmann JS; Yang Q; Heid IM; Rettig R; Dreisbach AW; Bochud M; Fox CS; Kao WH (2011)
      Identification of genetic risk factors for albuminuria may alter strategies for early prevention of CKD progression, particularly among patients with diabetes. Little is known about the influence of common genetic variants ...
    • Discovery and fine mapping of serum protein loci through transethnic meta-analysis 

      Franceschini N; van Rooij FJ; Prins BP; Feitosa MF; Karakas M; Eckfeldt JH; Folsom AR; Kopp J; Vaez A; Andrews JS; Baumert J; Boraska V; Broer L; Hayward C; Ngwa JS; Okada Y; Polasek O; Westra HJ; Wang YA; Del Greco M F; Glazer NL; Kapur K; Kema IP; Lopez LM; Schillert A; Smith AV; Winkler CA; Zgaga L; LifeLines Cohort Study; Bandinelli S; Bergmann S; Boban M; Bochud M; Chen YD; Davies G; Dehghan A; Ding J; Doering A; Durda JP; Ferrucci L; Franco OH; Franke L; Gunjaca G; Hofman A; Hsu FC; Kolcic I; Kraja A; Kubo M; Lackner KJ; Launer L; Loehr LR; Li G; Meisinger C; Nakamura Y; Schwienbacher C; Starr JM; Takahashi A; Torlak V; Uitterlinden AG; Vitart V; Waldenberger M; Wild PS; Kirin M; Zeller T; Zemunik T; Zhang Q; Ziegler A; Blankenberg S; Boerwinkle E; Borecki IB; Campbell H; Deary IJ; Frayling TM; Gieger C; Harris TB; Hicks AA; Koenig W; O' Donnell CJ; Fox CS; Pramstaller PP; Psaty BM; Reiner AP; Rotter JI; Rudan I; Snieder H; Tanaka T; van Duijn CM; Vollenweider P; Waeber G; Wilson JF; Witteman JC; Wolffenbuttel BH; Wright AF; Wu Q; Liu Y; Jenny NS; North KE; Felix JF; Alizadeh BZ; Cupples LA; Perry JR; Morris AP (2012)
      Many disorders are associated with altered serum protein concentrations, including malnutrition, cancer, and cardiovascular, kidney, and inflammatory diseases. Although these protein concentrations are highly heritable, ...
    • Discovery and fine mapping of serum protein loci through transethnic meta-analysis 

      Franceschini N; van Rooij FJ; Prins BP; Feitosa MF; Karakas M; Eckfeldt JH; Folsom AR; Kopp J; Vaez A; Andrews JS; Baumert J; Boraska V; Broer L; Hayward C; Ngwa JS; Okada Y; Polasek O; Westra HJ; Wang YA; Del Greco M F; Glazer NL; Kapur K; Kema IP; Lopez LM; Schillert A; Smith AV; Winkler CA; Zgaga L; LifeLines Cohort Study; Bandinelli S; Bergmann S; Boban M; Bochud M; Chen YD; Davies G; Dehghan A; Ding J; Doering A; Durda JP; Ferrucci L; Franco OH; Franke L; Gunjaca G; Hofman A; Hsu FC; Kolcic I; Kraja A; Kubo M; Lackner KJ; Launer L; Loehr LR; Li G; Meisinger C; Nakamura Y; Schwienbacher C; Starr JM; Takahashi A; Torlak V; Uitterlinden AG; Vitart V; Waldenberger M; Wild PS; Kirin M; Zeller T; Zemunik T; Zhang Q; Ziegler A; Blankenberg S; Boerwinkle E; Borecki IB; Campbell H; Deary IJ; Frayling TM; Gieger C; Harris TB; Hicks AA; Koenig W; O' Donnell CJ; Fox CS; Pramstaller PP; Psaty BM; Reiner AP; Rotter JI; Rudan I; Snieder H; Tanaka T; van Duijn CM; Vollenweider P; Waeber G; Wilson JF; Witteman JC; Wolffenbuttel BH; Wright AF; Wu Q; Liu Y; Jenny NS; North KE; Felix JF; Alizadeh BZ; Cupples LA; Perry JR; Morris AP (2012)
      Many disorders are associated with altered serum protein concentrations, including malnutrition, cancer, and cardiovascular, kidney, and inflammatory diseases. Although these protein concentrations are highly heritable, ...
    • FTO genotype is associated with phenotypic variability of body mass index 

      Yang J; Loos RJ; Powell JE; Medland SE; Speliotes EK; Chasman DI; Rose LM; Thorleifsson G; Steinthorsdottir V; Mägi R; Waite L; Smith AV; Yerges-Armstrong LM; Monda KL; Hadley D; Mahajan A; Li G; Kapur K; Vitart V; Huffman JE; Wang SR; Palmer C; Esko T; Fischer K; Zhao JH; Demirkan A; Isaacs A; Feitosa MF; Luan J; Heard-Costa NL; White C; Jackson AU; Preuss M; Ziegler A; Eriksson J; Kutalik Z; Frau F; Nolte IM; van Vliet-Ostaptchouk JV; Hottenga JJ; Jacobs KB; Verweij N; Goel A; Medina-Gomez C; Estrada K; Bragg-Gresham JL; Sanna S; Sidore C; Tyrer J; Teumer A; Prokopenko I; Mangino M; Lindgren CM; Assimes TL; Shuldiner AR; Hui J; Beilby JP; McArdle WL; Hall P; Haritunians T; Zgaga L; Kolcic I; Polasek O; Zemunik T; Oostra BA; Junttila MJ; Grönberg H; Schreiber S; Peters A; Hicks AA; Stephens J; Foad NS; Laitinen J; Pouta A; Kaakinen M; Willemsen G; Vink JM; Wild SH; Navis G; Asselbergs FW; Homuth G; John U; Iribarren C; Harris T; Launer L; Gudnason V; O'Connell JR; Boerwinkle E; Cadby G; Palmer LJ; James AL; Musk AW; Ingelsson E; Psaty BM; Beckmann JS; Waeber G; Vollenweider P; Hayward C; Wright AF; Rudan I; Groop LC; Metspalu A; Khaw KT; van Duijn CM; Borecki IB; Province MA; Wareham NJ; Tardif JC; Huikuri HV; Cupples LA; Atwood LD; Fox CS; Boehnke M; Collins FS; Mohlke KL; Erdmann J; Schunkert H; Hengstenberg C; Stark K; Lorentzon M; Ohlsson C; Cusi D; Staessen JA; van der Klauw MM; Pramstaller PP; Kathiresan S; Jolley JD; Ripatti S; Jarvelin MR; de Geus EJ; Boomsma DI; Penninx B; Wilson JF; Campbell H; Chanock SJ; van der Harst P; Hamsten A; Watkins H; Hofman A; Witteman JC; Zillikens MC; Uitterlinden AG; Rivadeneira F; Kiemeney LA; Vermeulen SH; Abecasis GR; Schlessinger D; Schipf S; Stumvoll M; Tönjes A; Spector TD; North KE; Lettre G; McCarthy MI; Berndt SI; Heath AC; Madden PA; Nyholt DR; Montgomery GW; Martin NG; McKnight B; Strachan DP; Hill WG; Snieder H; Ridker PM; Thorsteinsdottir U; Stefansson K; Frayling TM; Hirschhorn JN; Goddard ME; Visscher PM (2012)
      There is evidence across several species for genetic control of phenotypic variation of complex traits, such that the variance among phenotypes is genotype dependent. Understanding genetic control of variability is important ...
    • Genetic studies of body mass index yield new insights for obesity biology 

      Locke AE; Kahali B; Berndt SI; Justice AE; Pers TH; Day FR; Powell C; Vedantam S; Buchkovich ML; Yang J; Croteau-Chonka DC; Esko T; Fall T; Ferreira T; Gustafsson S; Kutalik Z; Luan J; Mägi R; Randall JC; Winkler TW; Wood AR; Workalemahu T; Faul JD; Smith JA; Hua Zhao J; Zhao W; Chen J; Fehrmann R; Hedman ÅK; Karjalainen J; Schmidt EM; Absher D; Amin N; Anderson D; Beekman M; Bolton JL; Bragg-Gresham JL; Buyske S; Demirkan A; Deng G; Ehret GB; Feenstra B; Feitosa MF; Fischer K; Goel A; Gong J; Jackson AU; Kanoni S; Kleber ME; Kristiansson K; Lim U; Lotay V; Mangino M; Mateo Leach I; Medina-Gomez C; Medland SE; Nalls MA; Palmer CD; Pasko D; Pechlivanis S; Peters MJ; Prokopenko I; Shungin D; Stančáková A; Strawbridge RJ; Ju Sung Y; Tanaka T; Teumer A; Trompet S; van der Laan SW; van Setten J; van Vliet-Ostaptchouk JV; Wang Z; Yengo L; Zhang W; Isaacs A; Albrecht E; Ärnlöv J; Arscott GM; Attwood AP; Bandinelli S; Barrett A; Bas IN; Bellis C; Bennett AJ; Berne C; Blagieva R; Blüher M; Böhringer S; Bonnycastle LL; Böttcher Y; Boyd HA; Bruinenberg M; Caspersen IH; Ida Chen YD; Clarke R; Daw EW; de Craen AJ; Delgado G; Dimitriou M; Doney AS; Eklund N; Estrada K; Eury E; Folkersen L; Fraser RM; Garcia ME; Geller F; Giedraitis V; Gigante B; Go AS; Golay A; Goodall AH; Gordon SD; Gorski M; Grabe HJ; Grallert H; Grammer TB; Gräßler J; Grönberg H; Groves CJ; Gusto G; Haessler J; Hall P; Haller T; Hallmans G; Hartman CA; Hassinen M; Hayward C; Heard-Costa NL; Helmer Q; Hengstenberg C; Holmen O; Hottenga JJ; James AL; Jeff JM; Johansson Å; Jolley J; Juliusdottir T; Kinnunen L; Koenig W; Koskenvuo M; Kratzer W; Laitinen J; Lamina C; Leander K; Lee NR; Lichtner P; Lind L; Lindström J; Sin Lo K; Lobbens S; Lorbeer R; Lu Y; Mach F; Magnusson PK; Mahajan A; McArdle WL; McLachlan S; Menni C; Merger S; Mihailov E; Milani L; Moayyeri A; Monda KL; Morken MA; Mulas A; Müller G; Müller-Nurasyid M; Musk AW; Nagaraja R; Nöthen MM; Nolte IM; Pilz S; Rayner NW; Renstrom F; Rettig R; Ried JS; Ripke S; Robertson NR; Rose LM; Sanna S; Scharnagl H; Scholtens S; Schumacher FR; Scott WR; Seufferlein T; Shi J; Vernon Smith A; Smolonska J; Stanton AV; Steinthorsdottir V; Stirrups K; Stringham HM; Sundström J; Swertz MA; Swift AJ; Syvänen AC; Tan ST; Tayo BO; Thorand B; Thorleifsson G; Tyrer JP; Uh HW; Vandenput L; Verhulst FC; Vermeulen SH; Verweij N; Vonk JM; Waite LL; Warren HR; Waterworth D; Weedon MN; Wilkens LR; Willenborg C; Wilsgaard T; Wojczynski MK; Wong A; Wright AF; Zhang Q; LifeLines Cohort Study; Brennan EP; Choi M; Dastani Z; Drong AW; Eriksson P; Franco-Cereceda A; Gådin JR; Gharavi AG; Goddard ME; Handsaker RE; Huang J; Karpe F; Kathiresan S; Keildson S; Kiryluk K; Kubo M; Lee JY; Liang L; Lifton RP; Ma B; McCarroll SA; McKnight AJ; Min JL; Moffatt MF; Montgomery GW; Murabito JM; Nicholson G; Nyholt DR; Okada Y; Perry JR; Dorajoo R; Reinmaa E; Salem RM; Sandholm N; Scott RA; Stolk L; Takahashi A; Van't Hooft FM; Vinkhuyzen AA; Westra HJ; Zheng W; Zondervan KT; ADIPOGen Consortium; AGEN-BMI Working Group; CARDIOGRAMplusC4D Consortium; CKDGen Consortium; GLGC; ICBP; MAGIC Investigators; MuTHER Consortium; MIGen Consortium; PAGE Consortium; ReproGen Consortium; GENIE Consortium; International Endogene Consortium; Heath AC; Arveiler D; Bakker SJ; Beilby J; Bergman RN; Blangero J; Bovet P; Campbell H; Caulfield MJ; Cesana G; Chakravarti A; Chasman DI; Chines PS; Collins FS; Crawford DC; Cupples LA; Cusi D; Danesh J; de Faire U; den Ruijter HM; Dominiczak AF; Erbel R; Erdmann J; Eriksson JG; Farrall M; Felix SB; Ferrannini E; Ferrières J; Ford I; Forouhi NG; Forrester T; Franco OH; Gansevoort RT; Gejman PV; Gieger C; Gottesman O; Gudnason V; Gyllensten U; Hall AS; Harris TB; Hattersley AT; Hicks AA; Hindorff LA; Hingorani AD; Hofman A; Homuth G; Hovingh GK; Humphries SE; Hunt SC; Hyppönen E; Illig T; Jacobs KB; Jarvelin MR; Jöckel KH; Johansen B; Jousilahti P; Jukema JW; Jula AM; Kaprio J; Kastelein JJ; Keinanen-Kiukaanniemi SM; Kiemeney LA; Knekt P; Kooner JS; Kooperberg C; Kovacs P; Kraja AT; Kumari M; Kuusisto J; Lakka TA; Langenberg C; Le Marchand L; Lehtimäki T; Lyssenko V; Männistö S; Marette A; Matise TC; McKenzie CA; McKnight B; Moll FL; Morris AD; Morris AP; Murray JC; Nelis M; Ohlsson C; Oldehinkel AJ; Ong KK; Madden PA; Pasterkamp G; Peden JF; Peters A; Postma DS; Pramstaller PP; Price JF; Qi L; Raitakari OT; Rankinen T; Rao DC; Rice TK; Ridker PM; Rioux JD; Ritchie MD; Rudan I; Salomaa V; Samani NJ; Saramies J; Sarzynski MA; Schunkert H; Schwarz PE; Sever P; Shuldiner AR; Sinisalo J; Stolk RP; Strauch K; Tönjes A; Trégouët DA; Tremblay A; Tremoli E; Virtamo J; Vohl MC; Völker U; Waeber G; Willemsen G; Witteman JC; Zillikens MC; Adair LS; Amouyel P; Asselbergs FW; Assimes TL; Bochud M; Boehm BO; Boerwinkle E; Bornstein SR; Bottinger EP; Bouchard C; Cauchi S; Chambers JC; Chanock SJ; Cooper RS; de Bakker PI; Dedoussis G; Ferrucci L; Franks PW; Froguel P; Groop LC; Haiman CA; Hamsten A; Hui J; Hunter DJ; Hveem K; Kaplan RC; Kivimaki M; Kuh D; Laakso M; Liu Y; Martin NG; März W; Melbye M; Metspalu A; Moebus S; Munroe PB; Njølstad I; Oostra BA; Palmer CN; Pedersen NL; Perola M; Pérusse L; Peters U; Power C; Quertermous T; Rauramaa R; Rivadeneira F; Saaristo TE; Saleheen D; Sattar N; Schadt EE; Schlessinger D; Slagboom PE; Snieder H; Spector TD; Thorsteinsdottir U; Stumvoll M; Tuomilehto J; Uitterlinden AG; Uusitupa M; van der Harst P; Walker M; Wallaschofski H; Wareham NJ; Watkins H; Weir DR; Wichmann HE; Wilson JF; Zanen P; Borecki IB; Deloukas P; Fox CS; Heid IM; O'Connell JR; Strachan DP; Stefansson K; van Duijn CM; Abecasis GR; Franke L; Frayling TM; McCarthy MI; Visscher PM; Scherag A; Willer CJ; Boehnke M; Mohlke KL; Lindgren CM; Beckmann JS; Barroso I; North KE; Ingelsson E; Hirschhorn JN; Loos RJ; Speliotes EK (2015)
      Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure ...
    • A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance 

      Manning AK; Hivert MF; Scott RA; Grimsby JL; Bouatia-Naji N; Chen H; Rybin D; Liu CT; Bielak LF; Prokopenko I; Amin N; Barnes D; Cadby G; Hottenga JJ; Ingelsson E; Jackson AU; Johnson T; Kanoni S; Ladenvall C; Lagou V; Lahti J; Lecoeur C; Liu Y; Martinez-Larrad MT; Montasser ME; Navarro P; Perry JR; Rasmussen-Torvik LJ; Salo P; Sattar N; Shungin D; Strawbridge RJ; Tanaka T; van Duijn CM; An P; de Andrade M; Andrews JS; Aspelund T; Atalay M; Aulchenko Y; Balkau B; Bandinelli S; Beckmann JS; Beilby JP; Bellis C; Bergman RN; Blangero J; Boban M; Boehnke M; Boerwinkle E; Bonnycastle LL; Boomsma DI; Borecki IB; Böttcher Y; Bouchard C; Brunner E; Budimir D; Campbell H; Carlson O; Chines PS; Clarke R; Collins FS; Corbatón-Anchuelo A; Couper D; de Faire U; Dedoussis GV; Deloukas P; Dimitriou M; Egan JM; Eiriksdottir G; Erdos MR; Eriksson JG; Eury E; Ferrucci L; Ford I; Forouhi NG; Fox CS; Franzosi MG; Franks PW; Frayling TM; Froguel P; Galan P; de Geus E; Gigante B; Glazer NL; Goel A; Groop L; Gudnason V; Hallmans G; Hamsten A; Hansson O; Harris TB; Hayward C; Heath S; Hercberg S; Hicks AA; Hingorani A; Hofman A; Hui J; Hung J; Jarvelin MR; Jhun MA; Johnson PC; Jukema JW; Jula A; Kao WH; Kaprio J; Kardia SL; Keinanen-Kiukaanniemi S; Kivimaki M; Kolcic I; Kovacs P; Kumari M; Kuusisto J; Kyvik KO; Laakso M; Lakka T; Lannfelt L; Lathrop GM; Launer LJ; Leander K; Li G; Lind L; Lindstrom J; Lobbens S; Loos RJ; Luan J; Lyssenko V; Mägi R; Magnusson PK; Marmot M; Meneton P; Mohlke KL; Mooser V; Morken MA; Miljkovic I; Narisu N; O'Connell J; Ong KK; Oostra BA; Palmer LJ; Palotie A; Pankow JS; Peden JF; Pedersen NL; Pehlic M; Peltonen L; Penninx B; Pericic M; Perola M; Perusse L; Peyser PA; Polasek O; Pramstaller PP; Province MA; Räikkönen K; Rauramaa R; Rehnberg E; Rice K; Rotter JI; Rudan I; Ruokonen A; Saaristo T; Sabater-Lleal M; Salomaa V; Savage DB; Saxena R; Schwarz P; Seedorf U; Sennblad B; Serrano-Ríos M; Shuldiner AR; Sijbrands EJ; Siscovick DS; Smit JH; Small KS; Smith NL; Smith AV; Stancáková A; Stirrups K; Stumvoll M; Sun YV; Swift AJ; Tönjes A; Tuomilehto J; Trompet S; Uitterlinden AG; Uusitupa M; Vikström M; Vitart V; Vohl MC; Voight BF; Vollenweider P; Waeber G; Waterworth DM; Watkins H; Wheeler E; Widen E; Wild SH; Willems SM; Willemsen G; Wilson JF; Witteman JC; Wright AF; Yaghootkar H; Zelenika D; Zemunik T; Zgaga L; DIAGRAM Consortium; MuTHER Consortium; Wareham NJ; McCarthy MI; Barroso I; Watanabe RM; Florez JC; Dupuis J; Meigs JB; Langenberg C (2012)
      Recent genome-wide association studies have described many loci implicated in type 2 diabetes (T2D) pathophysiology and β-cell dysfunction but have contributed little to the understanding of the genetic basis of insulin ...
    • Genome-wide association analyses identify 18 new loci associated with serum urate concentrations 

      Köttgen A; Albrecht E; Teumer A; Vitart V; Krumsiek J; Hundertmark C; Pistis G; Ruggiero D; O'Seaghdha CM; Haller T; Yang Q; Tanaka T; Johnson AD; Kutalik Z; Smith AV; Shi J; Struchalin M; Middelberg RP; Brown MJ; Gaffo AL; Pirastu N; Li G; Hayward C; Zemunik T; Huffman J; Yengo L; Zhao JH; Demirkan A; Feitosa MF; Liu X; Malerba G; Lopez LM; van der Harst P; Li X; Kleber ME; Hicks AA; Nolte IM; Johansson A; Murgia F; Wild SH; Bakker SJ; Peden JF; Dehghan A; Steri M; Tenesa A; Lagou V; Salo P; Mangino M; Rose LM; Lehtimäki T; Woodward OM; Okada Y; Tin A; Müller C; Oldmeadow C; Putku M; Czamara D; Kraft P; Frogheri L; Thun GA; Grotevendt A; Gislason GK; Harris TB; Launer LJ; McArdle P; Shuldiner AR; Boerwinkle E; Coresh J; Schmidt H; Schallert M; Martin NG; Montgomery GW; Kubo M; Nakamura Y; Munroe PB; Samani NJ; Jacobs DR; Liu K; D'Adamo P; Ulivi S; Rotter JI; Psaty BM; Vollenweider P; Waeber G; Campbell S; Devuyst O; Navarro P; Kolcic I; Hastie N; Balkau B; Froguel P; Esko T; Salumets A; Khaw KT; Langenberg C; Wareham NJ; Isaacs A; Kraja A; Zhang Q; Wild PS; Scott RJ; Holliday EG; Org E; Viigimaa M; Bandinelli S; Metter JE; Lupo A; Trabetti E; Sorice R; Döring A; Lattka E; Strauch K; Theis F; Waldenberger M; Wichmann HE; Davies G; Gow AJ; Bruinenberg M; LifeLines Cohort Study; Stolk RP; Kooner JS; Zhang W; Winkelmann BR; Boehm BO; Lucae S; Penninx BW; Smit JH; Curhan G; Mudgal P; Plenge RM; Portas L; Persico I; Kirin M; Wilson JF; Mateo Leach I; van Gilst WH; Goel A; Ongen H; Hofman A; Rivadeneira F; Uitterlinden AG; Imboden M; von Eckardstein A; Cucca F; Nagaraja R; Piras MG; Nauck M; Schurmann C; Budde K; Ernst F; Farrington SM; Theodoratou E; Prokopenko I; Stumvoll M; Jula A; Perola M; Salomaa V; Shin SY; Spector TD; Sala C; Ridker PM; Kähönen M; Viikari J; Hengstenberg C; Nelson CP; CARDIoGRAM Consortium; DIAGRAM Consortium; ICBP Consortium; MAGIC Consortium; Meschia JF; Nalls MA; Sharma P; Singleton AB; Kamatani N; Zeller T; Burnier M; Attia J; Laan M; Klopp N; Hillege HL; Kloiber S; Choi H; Pirastu M; Tore S; Probst-Hensch NM; Völzke H; Gudnason V; Parsa A; Schmidt R; Whitfield JB; Fornage M; Gasparini P; Siscovick DS; Polašek O; Campbell H; Rudan I; Bouatia-Naji N; Metspalu A; Loos RJ; van Duijn CM; Borecki IB; Ferrucci L; Gambaro G; Deary IJ; Wolffenbuttel BH; Chambers JC; März W; Pramstaller PP; Snieder H; Gyllensten U; Wright AF; Navis G; Watkins H; Witteman JC; Sanna S; Schipf S; Dunlop MG; Tönjes A; Ripatti S; Soranzo N; Toniolo D; Chasman DI; Raitakari O; Kao WH; Ciullo M; Fox CS; Caulfield M; Bochud M; Gieger C (2013)
      Elevated serum urate concentrations can cause gout, a prevalent and painful inflammatory arthritis. By combining data from >140,000 individuals of European ancestry within the Global Urate Genetics Consortium (GUGC), we ...
    • Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes 

      Teumer A; Tin A; Sorice R; Gorski M; Yeo NC; Chu AY; Li M; Li Y; Mijatovic V; Ko YA; Taliun D; Luciani A; Chen MH; Yang Q; Foster MC; Olden M; Hiraki LT; Tayo BO; Fuchsberger C; Dieffenbach AK; Shuldiner AR; Smith AV; Zappa AM; Lupo A; Kollerits B; Ponte B; Stengel B; Krämer BK; Paulweber B; Mitchell BD; Hayward C; Helmer C; Meisinger C; Gieger C; Shaffer CM; Müller C; Langenberg C; Ackermann D; Siscovick D; DCCT/EDIC; Boerwinkle E; Kronenberg F; Ehret GB; Homuth G; Waeber G; Navis G; Gambaro G; Malerba G; Eiriksdottir G; Li G; Wichmann HE; Grallert H; Wallaschofski H; Völzke H; Brenner H; Kramer H; Mateo Leach I; Rudan I; Hillege HL; Beckmann JS; Lambert JC; Luan J; Zhao JH; Chalmers J; Coresh J; Denny JC; Butterbach K; Launer LJ; Ferrucci L; Kedenko L; Haun M; Metzger M; Woodward M; Hoffman MJ; Nauck M; Waldenberger M; Pruijm M; Bochud M; Rheinberger M; Verweij N; Wareham NJ; Endlich N; Soranzo N; Polasek O; van der Harst P; Pramstaller PP; Vollenweider P; Wild PS; Gansevoort RT; Rettig R; Biffar R; Carroll RJ; Katz R; Loos RJ; Hwang SJ; Coassin S; Bergmann S; Rosas SE; Stracke S; Harris TB; Corre T; Zeller T; Illig T; Aspelund T; Tanaka T; Lendeckel U; Völker U; Gudnason V; Chouraki V; Koenig W; Kutalik Z; O'Connell JR; Parsa A; Heid IM; Paterson AD; de Boer IH; Devuyst O; Lazar J; Endlich K; Susztak K; Tremblay J; Hamet P; Jacob HJ; Böger CA; Fox CS; Pattaro C; Köttgen A (2016)
      Elevated concentrations of albumin in the urine, albuminuria, are a hallmark of diabetic kidney disease and are associated with an increased risk for end-stage renal disease and cardiovascular events. To gain insight into ...
    • Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma 

      Chambers JC; Zhang W; Sehmi J; Li X; Wass MN; van der Harst P; Holm H; Sanna S; Kavousi M; Baumeister SE; Coin LJ; Deng G; Gieger C; Heard-Costa NL; Hottenga JJ; Kühnel B; Kumar V; Lagou V; Liang L; Luan J; Vidal PM; Mateo Leach I; O'Reilly PF; Peden JF; Rahmioglu N; Soininen P; Speliotes EK; Yuan X; Thorleifsson G; Alizadeh BZ; Atwood LD; Borecki IB; Brown MJ; Charoen P; Cucca F; Das D; de Geus EJ; Dixon AL; Döring A; Ehret G; Eyjolfsson GI; Farrall M; Forouhi NG; Friedrich N; Goessling W; Gudbjartsson DF; Harris TB; Hartikainen AL; Heath S; Hirschfield GM; Hofman A; Homuth G; Hyppönen E; Janssen HL; Johnson T; Kangas AJ; Kema IP; Kühn JP; Lai S; Lathrop M; Lerch MM; Li Y; Liang TJ; Lin JP; Loos RJ; Martin NG; Moffatt MF; Montgomery GW; Munroe PB; Musunuru K; Nakamura Y; O'Donnell CJ; Olafsson I; Penninx BW; Pouta A; Prins BP; Prokopenko I; Puls R; Ruokonen A; Savolainen MJ; Schlessinger D; Schouten JN; Seedorf U; Sen-Chowdhry S; Siminovitch KA; Smit JH; Spector TD; Tan W; Teslovich TM; Tukiainen T; Uitterlinden AG; van der Klauw MM; Vasan RS; Wallace C; Wallaschofski H; Wichmann HE; Willemsen G; Würtz P; Xu C; Yerges-Armstrong LM; Alcohol Genome-wide Association (AlcGen) Consortium; DIAGRAM Consortium; Genetic Investigation of Anthropometric Traits (GIANT) Consortium; Global Lipids Genetics Consortium; Genetics of Liver Disease (GOLD) Consortium; International Consortium for Blood Pressure (ICBP-GWAS); MAGIC Consortium; Abecasis GR; Ahmadi KR; Boomsma DI; Caulfield M; Cookson WO; van Duijn CM; Froguel P; Matsuda K; McCarthy MI; Meisinger C; Mooser V; Pietiläinen KH; Schumann G; Snieder H; Sternberg MJ; Stolk RP; Thomas HC; Thorsteinsdottir U; Uda M; Waeber G; Wareham NJ; Waterworth DM; Watkins H; Whitfield JB; Witteman JC; Wolffenbuttel BH; Fox CS; Ala-Korpela M; Stefansson K; Vollenweider P; Völzke H; Schadt EE; Scott J; Järvelin MR; Elliott P; Kooner JS (2011)
      Concentrations of liver enzymes in plasma are widely used as indicators of liver disease. We carried out a genome-wide association study in 61,089 individuals, identifying 42 loci associated with concentrations of liver ...
    • Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure 

      Wain LV; Verwoert GC; O'Reilly PF; Shi G; Johnson T; Johnson AD; Bochud M; Rice KM; Henneman P; Smith AV; Ehret GB; Amin N; Larson MG; Mooser V; Hadley D; Dörr M; Bis JC; Aspelund T; Esko T; Janssens AC; Zhao JH; Heath S; Laan M; Fu J; Pistis G; Luan J; Arora P; Lucas G; Pirastu N; Pichler I; Jackson AU; Webster RJ; Zhang F; Peden JF; Schmidt H; Tanaka T; Campbell H; Igl W; Milaneschi Y; Hottenga JJ; Vitart V; Chasman DI; Trompet S; Bragg-Gresham JL; Alizadeh BZ; Chambers JC; Guo X; Lehtimäki T; Kühnel B; Lopez LM; Polašek O; Boban M; Nelson CP; Morrison AC; Pihur V; Ganesh SK; Hofman A; Kundu S; Mattace-Raso FU; Rivadeneira F; Sijbrands EJ; Uitterlinden AG; Hwang SJ; Vasan RS; Wang TJ; Bergmann S; Vollenweider P; Waeber G; Laitinen J; Pouta A; Zitting P; McArdle WL; Kroemer HK; Völker U; Völzke H; Glazer NL; Taylor KD; Harris TB; Alavere H; Haller T; Keis A; Tammesoo ML; Aulchenko Y; Barroso I; Khaw KT; Galan P; Hercberg S; Lathrop M; Eyheramendy S; Org E; Sõber S; Lu X; Nolte IM; Penninx BW; Corre T; Masciullo C; Sala C; Groop L; Voight BF; Melander O; O'Donnell CJ; Salomaa V; D'Adamo AP; Fabretto A; Faletra F; Ulivi S; Del Greco M F; Facheris M; Collins FS; Bergman RN; Beilby JP; Hung J; Musk AW; Mangino M; Shin SY; Soranzo N; Watkins H; Goel A; Hamsten A; Gider P; Loitfelder M; Zeginigg M; Hernandez D; Najjar SS; Navarro P; Wild SH; Corsi AM; Singleton A; de Geus EJ; Willemsen G; Parker AN; Rose LM; Buckley B; Stott D; Orru M; Uda M; LifeLines Cohort Study; van der Klauw MM; Zhang W; Li X; Scott J; Chen YD; Burke GL; Kähönen M; Viikari J; Döring A; Meitinger T; Davies G; Starr JM; Emilsson V; Plump A; Lindeman JH; Hoen PA; König IR; EchoGen consortium; Felix JF; Clarke R; Hopewell JC; Ongen H; Breteler M; Debette S; DeStefano AL; Fornage M; AortaGen Consortium; Mitchell GF; CHARGE Consortium Heart Failure Working Group; Smith NL; KidneyGen consortium; Holm H; Stefansson K; Thorleifsson G; Thorsteinsdottir U; CKDGen Consortium; Cardiogenics consortium; CARDIoGRAM Consortium; Samani NJ; Preuss M; Rudan I; Hayward C; Deary IJ; Wichmann HE; Raitakari OT; Palmas W; Kooner JS; Stolk RP; Jukema JW; Wright AF; Boomsma DI; Bandinelli S; Gyllensten UB; Wilson JF; Ferrucci L; Schmidt R; Farrall M; Spector TD; Palmer LJ; Tuomilehto J; Pfeufer A; Gasparini P; Siscovick D; Altshuler D; Loos RJ; Toniolo D; Snieder H; Gieger C; Meneton P; Wareham NJ; Oostra BA; Metspalu A; Launer L; Rettig R; Strachan DP; Beckmann JS; Witteman JC; Erdmann J; van Dijk KW; Boerwinkle E; Boehnke M; Ridker PM; Jarvelin MR; Chakravarti A; Abecasis GR; Gudnason V; Newton-Cheh C; Levy D; Munroe PB; Psaty BM; Caulfield MJ; Rao DC; Tobin MD; Elliott P; van Duijn CM (2011)
      Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans. We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure ...
    • Genome-wide association study of kidney function decline in individuals of European descent 

      Gorski M; Tin A; Garnaas M; McMahon GM; Chu AY; Tayo BO; Pattaro C; Teumer A; Chasman DI; Chalmers J; Hamet P; Tremblay J; Woodward M; Aspelund T; Eiriksdottir G; Gudnason V; Harris TB; Launer LJ; Smith AV; Mitchell BD; O'Connell JR; Shuldiner AR; Coresh J; Li M; Freudenberger P; Hofer E; Schmidt H; Schmidt R; Holliday EG; Mitchell P; Wang JJ; de Boer IH; Li G; Siscovick DS; Kutalik Z; Corre T; Vollenweider P; Waeber G; Gupta J; Kanetsky PA; Hwang SJ; Olden M; Yang Q; de Andrade M; Atkinson EJ; Kardia SL; Turner ST; Stafford JM; Ding J; Liu Y; Barlassina C; Cusi D; Salvi E; Staessen JA; Ridker PM; Grallert H; Meisinger C; Müller-Nurasyid M; Krämer BK; Kramer H; Rosas SE; Nolte IM; Penninx BW; Snieder H; Del Greco M F; Franke A; Nöthlings U; Lieb W; Bakker SJ; Gansevoort RT; van der Harst P; Dehghan A; Franco OH; Hofman A; Rivadeneira F; Sedaghat S; Uitterlinden AG; Coassin S; Haun M; Kollerits B; Kronenberg F; Paulweber B; Aumann N; Endlich K; Pietzner M; Völker U; Rettig R; Chouraki V; Helmer C; Lambert JC; Metzger M; Stengel B; Lehtimäki T; Lyytikäinen LP; Raitakari O; Johnson A; Parsa A; Bochud M; Heid IM; Goessling W; Köttgen A; Kao WH; Fox CS; Böger CA (2015)
      Genome-wide association studies (GWASs) have identified multiple loci associated with cross-sectional eGFR, but a systematic genetic analysis of kidney function decline over time is missing. Here we conducted a GWAS ...
    • Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture 

      Berndt SI; Gustafsson S; Mägi R; Ganna A; Wheeler E; Feitosa MF; Justice AE; Monda KL; Croteau-Chonka DC; Day FR; Esko T; Fall T; Ferreira T; Gentilini D; Jackson AU; Luan J; Randall JC; Vedantam S; Willer CJ; Winkler TW; Wood AR; Workalemahu T; Hu YJ; Lee SH; Liang L; Lin DY; Min JL; Neale BM; Thorleifsson G; Yang J; Albrecht E; Amin N; Bragg-Gresham JL; Cadby G; den Heijer M; Eklund N; Fischer K; Goel A; Hottenga JJ; Huffman JE; Jarick I; Johansson Å; Johnson T; Kanoni S; Kleber ME; König IR; Kristiansson K; Kutalik Z; Lamina C; Lecoeur C; Li G; Mangino M; McArdle WL; Medina-Gomez C; Müller-Nurasyid M; Ngwa JS; Nolte IM; Paternoster L; Pechlivanis S; Perola M; Peters MJ; Preuss M; Rose LM; Shi J; Shungin D; Smith AV; Strawbridge RJ; Surakka I; Teumer A; Trip MD; Tyrer J; van Vliet-Ostaptchouk JV; Vandenput L; Waite LL; Zhao JH; Absher D; Asselbergs FW; Atalay M; Attwood AP; Balmforth AJ; Basart H; Beilby J; Bonnycastle LL; Brambilla P; Bruinenberg M; Campbell H; Chasman DI; Chines PS; Collins FS; Connell JM; Cookson WO; de Faire U; de Vegt F; Dei M; Dimitriou M; Edkins S; Estrada K; Evans DM; Farrall M; Ferrario MM; Ferrières J; Franke L; Frau F; Gejman PV; Grallert H; Grönberg H; Gudnason V; Hall AS; Hall P; Hartikainen AL; Hayward C; Heard-Costa NL; Heath AC; Hebebrand J; Homuth G; Hu FB; Hunt SE; Hyppönen E; Iribarren C; Jacobs KB; Jansson JO; Jula A; Kähönen M; Kathiresan S; Kee F; Khaw KT; Kivimäki M; Koenig W; Kraja AT; Kumari M; Kuulasmaa K; Kuusisto J; Laitinen JH; Lakka TA; Langenberg C; Launer LJ; Lind L; Lindström J; Liu J; Liuzzi A; Lokki ML; Lorentzon M; Madden PA; Magnusson PK; Manunta P; Marek D; März W; Mateo Leach I; McKnight B; Medland SE; Mihailov E; Milani L; Montgomery GW; Mooser V; Mühleisen TW; Munroe PB; Musk AW; Narisu N; Navis G; Nicholson G; Nohr EA; Ong KK; Oostra BA; Palmer CN; Palotie A; Peden JF; Pedersen N; Peters A; Polasek O; Pouta A; Pramstaller PP; Prokopenko I; Pütter C; Radhakrishnan A; Raitakari O; Rendon A; Rivadeneira F; Rudan I; Saaristo TE; Sambrook JG; Sanders AR; Sanna S; Saramies J; Schipf S; Schreiber S; Schunkert H; Shin SY; Signorini S; Sinisalo J; Skrobek B; Soranzo N; Stancáková A; Stark K; Stephens JC; Stirrups K; Stolk RP; Stumvoll M; Swift AJ; Theodoraki EV; Thorand B; Tregouet DA; Tremoli E; van der Klauw MM; van Meurs JB; Vermeulen SH; Viikari J; Virtamo J; Vitart V; Waeber G; Wang Z; Widén E; Wild SH; Willemsen G; Winkelmann BR; Witteman JC; Wolffenbuttel BH; Wong A; Wright AF; Zillikens MC; Amouyel P; Boehm BO; Boerwinkle E; Boomsma DI; Caulfield MJ; Chanock SJ; Cupples LA; Cusi D; Dedoussis GV; Erdmann J; Eriksson JG; Franks PW; Froguel P; Gieger C; Gyllensten U; Hamsten A; Harris TB; Hengstenberg C; Hicks AA; Hingorani A; Hinney A; Hofman A; Hovingh KG; Hveem K; Illig T; Jarvelin MR; Jöckel KH; Keinanen-Kiukaanniemi SM; Kiemeney LA; Kuh D; Laakso M; Lehtimäki T; Levinson DF; Martin NG; Metspalu A; Morris AD; Nieminen MS; Njølstad I; Ohlsson C; Oldehinkel AJ; Ouwehand WH; Palmer LJ; Penninx B; Power C; Province MA; Psaty BM; Qi L; Rauramaa R; Ridker PM; Ripatti S; Salomaa V; Samani NJ; Snieder H; Sørensen TI; Spector TD; Stefansson K; Tönjes A; Tuomilehto J; Uitterlinden AG; Uusitupa M; van der Harst P; Vollenweider P; Wallaschofski H; Wareham NJ; Watkins H; Wichmann HE; Wilson JF; Abecasis GR; Assimes TL; Barroso I; Boehnke M; Borecki IB; Deloukas P; Fox CS; Frayling T; Groop LC; Haritunian T; Heid IM; Hunter D; Kaplan RC; Karpe F; Moffatt MF; Mohlke KL; O'Connell JR; Pawitan Y; Schadt EE; Schlessinger D; Steinthorsdottir V; Strachan DP; Thorsteinsdottir U; van Duijn CM; Visscher PM; Di Blasio AM; Hirschhorn JN; Lindgren CM; Morris AP; Meyre D; Scherag A; McCarthy MI; Speliotes EK; North KE; Loos RJ; Ingelsson E (2013)
      Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for ...
    • Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels 

      Kilpeläinen TO; Carli JF; Skowronski AA; Sun Q; Kriebel J; Feitosa MF; Hedman ÅK; Drong AW; Hayes JE; Zhao J; Pers TH; Schick U; Grarup N; Kutalik Z; Trompet S; Mangino M; Kristiansson K; Beekman M; Lyytikäinen LP; Eriksson J; Henneman P; Lahti J; Tanaka T; Luan J; Del Greco M F; Pasko D; Renström F; Willems SM; Mahajan A; Rose LM; Guo X; Liu Y; Kleber ME; Pérusse L; Gaunt T; Ahluwalia TS; Ju Sung Y; Ramos YF; Amin N; Amuzu A; Barroso I; Bellis C; Blangero J; Buckley BM; Böhringer S; I Chen YD; de Craen AJ; Crosslin DR; Dale CE; Dastani Z; Day FR; Deelen J; Delgado GE; Demirkan A; Finucane FM; Ford I; Garcia ME; Gieger C; Gustafsson S; Hallmans G; Hankinson SE; Havulinna AS; Herder C; Hernandez D; Hicks AA; Hunter DJ; Illig T; Ingelsson E; Ioan-Facsinay A; Jansson JO; Jenny NS; Jørgensen ME; Jørgensen T; Karlsson M; Koenig W; Kraft P; Kwekkeboom J; Laatikainen T; Ladwig KH; LeDuc CA; Lowe G; Lu Y; Marques-Vidal P; Meisinger C; Menni C; Morris AP; Myers RH; Männistö S; Nalls MA; Paternoster L; Peters A; Pradhan AD; Rankinen T; Rasmussen-Torvik LJ; Rathmann W; Rice TK; Brent Richards J; Ridker PM; Sattar N; Savage DB; Söderberg S; Timpson NJ; Vandenput L; van Heemst D; Uh HW; Vohl MC; Walker M; Wichmann HE; Widén E; Wood AR; Yao J; Zeller T; Zhang Y; Meulenbelt I; Kloppenburg M; Astrup A; Sørensen TI; Sarzynski MA; Rao DC; Jousilahti P; Vartiainen E; Hofman A; Rivadeneira F; Uitterlinden AG; Kajantie E; Osmond C; Palotie A; Eriksson JG; Heliövaara M; Knekt PB; Koskinen S; Jula A; Perola M; Huupponen RK; Viikari JS; Kähönen M; Lehtimäki T; Raitakari OT; Mellström D; Lorentzon M; Casas JP; Bandinelli S; März W; Isaacs A; van Dijk KW; van Duijn CM; Harris TB; Bouchard C; Allison MA; Chasman DI; Ohlsson C; Lind L; Scott RA; Langenberg C; Wareham NJ; Ferrucci L; Frayling TM; Pramstaller PP; Borecki IB; Waterworth DM; Bergmann S; Waeber G; Vollenweider P; Vestergaard H; Hansen T; Pedersen O; Hu FB; Eline Slagboom P; Grallert H; Spector TD; Jukema JW; Klein RJ; Schadt EE; Franks PW; Lindgren CM; Leibel RL; Loos RJ (2016)
      Leptin is an adipocyte-secreted hormone, the circulating levels of which correlate closely with overall adiposity. Although rare mutations in the leptin (LEP) gene are well known to cause leptin deficiency and severe ...
    • Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders 

      den Hoed M; Eijgelsheim M; Esko T; Brundel BJ; Peal DS; Evans DM; Nolte IM; Segrè AV; Holm H; Handsaker RE; Westra HJ; Johnson T; Isaacs A; Yang J; Lundby A; Zhao JH; Kim YJ; Go MJ; Almgren P; Bochud M; Boucher G; Cornelis MC; Gudbjartsson D; Hadley D; van der Harst P; Hayward C; den Heijer M; Igl W; Jackson AU; Kutalik Z; Luan J; Kemp JP; Kristiansson K; Ladenvall C; Lorentzon M; Montasser ME; Njajou OT; O'Reilly PF; Padmanabhan S; St Pourcain B; Rankinen T; Salo P; Tanaka T; Timpson NJ; Vitart V; Waite L; Wheeler W; Zhang W; Draisma HH; Feitosa MF; Kerr KF; Lind PA; Mihailov E; Onland-Moret NC; Song C; Weedon MN; Xie W; Yengo L; Absher D; Albert CM; Alonso A; Arking DE; de Bakker PI; Balkau B; Barlassina C; Benaglio P; Bis JC; Bouatia-Naji N; Brage S; Chanock SJ; Chines PS; Chung M; Darbar D; Dina C; Dörr M; Elliott P; Felix SB; Fischer K; Fuchsberger C; de Geus EJ; Goyette P; Gudnason V; Harris TB; Hartikainen AL; Havulinna AS; Heckbert SR; Hicks AA; Hofman A; Holewijn S; Hoogstra-Berends F; Hottenga JJ; Jensen MK; Johansson A; Junttila J; Kääb S; Kanon B; Ketkar S; Khaw KT; Knowles JW; Kooner AS; Kors JA; Kumari M; Milani L; Laiho P; Lakatta EG; Langenberg C; Leusink M; Liu Y; Luben RN; Lunetta KL; Lynch SN; Markus MR; Marques-Vidal P; Mateo Leach I; McArdle WL; McCarroll SA; Medland SE; Miller KA; Montgomery GW; Morrison AC; Müller-Nurasyid M; Navarro P; Nelis M; O'Connell JR; O'Donnell CJ; Ong KK; Newman AB; Peters A; Polasek O; Pouta A; Pramstaller PP; Psaty BM; Rao DC; Ring SM; Rossin EJ; Rudan D; Sanna S; Scott RA; Sehmi JS; Sharp S; Shin JT; Singleton AB; Smith AV; Soranzo N; Spector TD; Stewart C; Stringham HM; Tarasov KV; Uitterlinden AG; Vandenput L; Hwang SJ; Whitfield JB; Wijmenga C; Wild SH; Willemsen G; Wilson JF; Witteman JC; Wong A; Wong Q; Jamshidi Y; Zitting P; Boer JM; Boomsma DI; Borecki IB; van Duijn CM; Ekelund U; Forouhi NG; Froguel P; Hingorani A; Ingelsson E; Kivimaki M; Kronmal RA; Kuh D; Lind L; Martin NG; Oostra BA; Pedersen NL; Quertermous T; Rotter JI; van der Schouw YT; Verschuren WM; Walker M; Albanes D; Arnar DO; Assimes TL; Bandinelli S; Boehnke M; de Boer RA; Bouchard C; Caulfield WL; Chambers JC; Curhan G; Cusi D; Eriksson J; Ferrucci L; van Gilst WH; Glorioso N; de Graaf J; Groop L; Gyllensten U; Hsueh WC; Hu FB; Huikuri HV; Hunter DJ; Iribarren C; Isomaa B; Jarvelin MR; Jula A; Kähönen M; Kiemeney LA; van der Klauw MM; Kooner JS; Kraft P; Iacoviello L; Lehtimäki T; Lokki ML; Mitchell BD; Navis G; Nieminen MS; Ohlsson C; Poulter NR; Qi L; Raitakari OT; Rimm EB; Rioux JD; Rizzi F; Rudan I; Salomaa V; Sever PS; Shields DC; Shuldiner AR; Sinisalo J; Stanton AV; Stolk RP; Strachan DP; Tardif JC; Thorsteinsdottir U; Tuomilehto J; van Veldhuisen DJ; Virtamo J; Viikari J; Vollenweider P; Waeber G; Widen E; Cho YS; Olsen JV; Visscher PM; Willer C; Franke L; Global BPgen Consortium; CARDIoGRAM Consortium; Erdmann J; Thompson JR; PR GWAS Consortium; Pfeufer A; QRS GWAS Consortium; Sotoodehnia N; QT-IGC Consortium; Newton-Cheh C; CHARGE-AF Consortium; Ellinor PT; Stricker BH; Metspalu A; Perola M; Beckmann JS; Smith GD; Stefansson K; Wareham NJ; Munroe PB; Sibon OC; Milan DJ; Snieder H; Samani NJ; Loos RJ (2013)
      Elevated resting heart rate is associated with greater risk of cardiovascular disease and mortality. In a 2-stage meta-analysis of genome-wide association studies in up to 181,171 individuals, we identified 14 new loci ...
    • The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study 

      Winkler TW; Justice AE; Graff M; Barata L; Feitosa MF; Chu S; Czajkowski J; Esko T; Fall T; Kilpeläinen TO; Lu Y; Mägi R; Mihailov E; Pers TH; Rüeger S; Teumer A; Ehret GB; Ferreira T; Heard-Costa NL; Karjalainen J; Lagou V; Mahajan A; Neinast MD; Prokopenko I; Simino J; Teslovich TM; Jansen R; Westra HJ; White CC; Absher D; Ahluwalia TS; Ahmad S; Albrecht E; Alves AC; Bragg-Gresham JL; de Craen AJ; Bis JC; Bonnefond A; Boucher G; Cadby G; Cheng YC; Chiang CW; Delgado G; Demirkan A; Dueker N; Eklund N; Eiriksdottir G; Eriksson J; Feenstra B; Fischer K; Frau F; Galesloot TE; Geller F; Goel A; Gorski M; Grammer TB; Gustafsson S; Haitjema S; Hottenga JJ; Huffman JE; Jackson AU; Jacobs KB; Johansson Å; Kaakinen M; Kleber ME; Lahti J; Mateo Leach I; Lehne B; Liu Y; Lo KS; Lorentzon M; Luan J; Madden PA; Mangino M; McKnight B; Medina-Gomez C; Monda KL; Montasser ME; Müller G; Müller-Nurasyid M; Nolte IM; Panoutsopoulou K; Pascoe L; Paternoster L; Rayner NW; Renström F; Rizzi F; Rose LM; Ryan KA; Salo P; Sanna S; Scharnagl H; Shi J; Smith AV; Southam L; Stančáková A; Steinthorsdottir V; Strawbridge RJ; Sung YJ; Tachmazidou I; Tanaka T; Thorleifsson G; Trompet S; Pervjakova N; Tyrer JP; Vandenput L; van der Laan SW; van der Velde N; van Setten J; van Vliet-Ostaptchouk JV; Verweij N; Vlachopoulou E; Waite LL; Wang SR; Wang Z; Wild SH; Willenborg C; Wilson JF; Wong A; Yang J; Yengo L; Yerges-Armstrong LM; Yu L; Zhang W; Zhao JH; Andersson EA; Bakker SJ; Baldassarre D; Banasik K; Barcella M; Barlassina C; Bellis C; Benaglio P; Blangero J; Blüher M; Bonnet F; Bonnycastle LL; Boyd HA; Bruinenberg M; Buchman AS; Campbell H; Chen YD; Chines PS; Claudi-Boehm S; Cole J; Collins FS; de Geus EJ; de Groot LC; Dimitriou M; Duan J; Enroth S; Eury E; Farmaki AE; Forouhi NG; Friedrich N; Gejman PV; Gigante B; Glorioso N; Go AS; Gottesman O; Gräßler J; Grallert H; Grarup N; Gu YM; Broer L; Ham AC; Hansen T; Harris TB; Hartman CA; Hassinen M; Hastie N; Hattersley AT; Heath AC; Henders AK; Hernandez D; Hillege H; Holmen O; Hovingh KG; Hui J; Husemoen LL; Hutri-Kähönen N; Hysi PG; Illig T; De Jager PL; Jalilzadeh S; Jørgensen T; Jukema JW; Juonala M; Kanoni S; Karaleftheri M; Khaw KT; Kinnunen L; Kittner SJ; Koenig W; Kolcic I; Kovacs P; Krarup NT; Kratzer W; Krüger J; Kuh D; Kumari M; Kyriakou T; Langenberg C; Lannfelt L; Lanzani C; Lotay V; Launer LJ; Leander K; Lindström J; Linneberg A; Liu YP; Lobbens S; Luben R; Lyssenko V; Männistö S; Magnusson PK; McArdle WL; Menni C; Merger S; Milani L; Montgomery GW; Morris AP; Narisu N; Nelis M; Ong KK; Palotie A; Pérusse L; Pichler I; Pilia MG; Pouta A; Rheinberger M; Ribel-Madsen R; Richards M; Rice KM; Rice TK; Rivolta C; Salomaa V; Sanders AR; Sarzynski MA; Scholtens S; Scott RA; Scott WR; Sebert S; Sengupta S; Sennblad B; Seufferlein T; Silveira A; Slagboom PE; Smit JH; Sparsø TH; Stirrups K; Stolk RP; Stringham HM; Swertz MA; Swift AJ; Syvänen AC; Tan ST; Thorand B; Tönjes A; Tremblay A; Tsafantakis E; van der Most PJ; Völker U; Vohl MC; Vonk JM; Waldenberger M; Walker RW; Wennauer R; Widén E; Willemsen G; Wilsgaard T; Wright AF; Zillikens MC; van Dijk SC; van Schoor NM; Asselbergs FW; de Bakker PI; Beckmann JS; Beilby J; Bennett DA; Bergman RN; Bergmann S; Böger CA; Boehm BO; Boerwinkle E; Boomsma DI; Bornstein SR; Bottinger EP; Bouchard C; Chambers JC; Chanock SJ; Chasman DI; Cucca F; Cusi D; Dedoussis G; Erdmann J; Eriksson JG; Evans DA; de Faire U; Farrall M; Ferrucci L; Ford I; Franke L; Franks PW; Froguel P; Gansevoort RT; Gieger C; Grönberg H; Gudnason V; Gyllensten U; Hall P; Hamsten A; van der Harst P; Hayward C; Heliövaara M; Hengstenberg C; Hicks AA; Hingorani A; Hofman A; Hu F; Huikuri HV; Hveem K; James AL; Jordan JM; Jula A; Kähönen M; Kajantie E; Kathiresan S; Kiemeney LA; Kivimaki M; Knekt PB; Koistinen HA; Kooner JS; Koskinen S; Kuusisto J; Maerz W; Martin NG; Laakso M; Lakka TA; Lehtimäki T; Lettre G; Levinson DF; Lind L; Lokki ML; Mäntyselkä P; Melbye M; Metspalu A; Mitchell BD; Moll FL; Murray JC; Musk AW; Nieminen MS; Njølstad I; Ohlsson C; Oldehinkel AJ; Oostra BA; Palmer LJ; Pankow JS; Pasterkamp G; Pedersen NL; Pedersen O; Penninx BW; Perola M; Peters A; Polašek O; Pramstaller PP; Psaty BM; Qi L; Quertermous T; Raitakari OT; Rankinen T; Rauramaa R; Ridker PM; Rioux JD; Rivadeneira F; Rotter JI; Rudan I; den Ruijter HM; Saltevo J; Sattar N; Schunkert H; Schwarz PE; Shuldiner AR; Sinisalo J; Snieder H; Sørensen TI; Spector TD; Staessen JA; Stefania B; Thorsteinsdottir U; Stumvoll M; Tardif JC; Tremoli E; Tuomilehto J; Uitterlinden AG; Uusitupa M; Verbeek AL; Vermeulen SH; Viikari JS; Vitart V; Völzke H; Vollenweider P; Waeber G; Walker M; Wallaschofski H; Wareham NJ; Watkins H; Zeggini E; CHARGE Consortium; DIAGRAM Consortium; GLGC Consortium; Global-BPGen Consortium; ICBP Consortium; MAGIC Consortium; Chakravarti A; Clegg DJ; Cupples LA; Gordon-Larsen P; Jaquish CE; Rao DC; Abecasis GR; Assimes TL; Barroso I; Berndt SI; Boehnke M; Deloukas P; Fox CS; Groop LC; Hunter DJ; Ingelsson E; Kaplan RC; McCarthy MI; Mohlke KL; O'Connell JR; Schlessinger D; Strachan DP; Stefansson K; van Duijn CM; Hirschhorn JN; Lindgren CM; Heid IM; North KE; Borecki IB; Kutalik Z; Loos RJ (2015)
      Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and ...
    • Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations 

      Kolz M; Johnson T; Sanna S; Teumer A; Vitart V; Perola M; Mangino M; Albrecht E; Wallace C; Farrall M; Johansson A; Nyholt DR; Aulchenko Y; Beckmann JS; Bergmann S; Bochud M; Brown M; Campbell H; EUROSPAN Consortium; Connell J; Dominiczak A; Homuth G; Lamina C; McCarthy MI; ENGAGE Consortium; Meitinger T; Mooser V; Munroe P; Nauck M; Peden J; Prokisch H; Salo P; Salomaa V; Samani NJ; Schlessinger D; Uda M; Völker U; Waeber G; Waterworth D; Wang-Sattler R; Wright AF; Adamski J; Whitfield JB; Gyllensten U; Wilson JF; Rudan I; Pramstaller P; Watkins H; PROCARDIS Consortium; Doering A; Wichmann HE; KORA Study; Spector TD; Peltonen L; Völzke H; Nagaraja R; Vollenweider P; Caulfield M; WTCCC; Illig T; Gieger C (2009)
      Elevated serum uric acid levels cause gout and are a risk factor for cardiovascular disease and diabetes. To investigate the polygenetic basis of serum uric acid levels, we conducted a meta-analysis of genome-wide association ...
    • Modulation of genetic associations with serum urate levels by body-mass-index in humans 

      Huffman JE; Albrecht E; Teumer A; Mangino M; Kapur K; Johnson T; Kutalik Z; Pirastu N; Pistis G; Lopez LM; Haller T; Salo P; Goel A; Li M; Tanaka T; Dehghan A; Ruggiero D; Malerba G; Smith AV; Nolte IM; Portas L; Phipps-Green A; Boteva L; Navarro P; Johansson A; Hicks AA; Polasek O; Esko T; Peden JF; Harris SE; Murgia F; Wild SH; Tenesa A; Tin A; Mihailov E; Grotevendt A; Gislason GK; Coresh J; D'Adamo P; Ulivi S; Vollenweider P; Waeber G; Campbell S; Kolcic I; Fisher K; Viigimaa M; Metter JE; Masciullo C; Trabetti E; Bombieri C; Sorice R; Döring A; Reischl E; Strauch K; Hofman A; Uitterlinden AG; Waldenberger M; Wichmann HE; Davies G; Gow AJ; Dalbeth N; Stamp L; Smit JH; Kirin M; Nagaraja R; Nauck M; Schurmann C; Budde K; Farrington SM; Theodoratou E; Jula A; Salomaa V; Sala C; Hengstenberg C; Burnier M; Mägi R; Klopp N; Kloiber S; Schipf S; Ripatti S; Cabras S; Soranzo N; Homuth G; Nutile T; Munroe PB; Hastie N; Campbell H; Rudan I; Cabrera C; Haley C; Franco OH; Merriman TR; Gudnason V; Pirastu M; Penninx BW; Snieder H; Metspalu A; Ciullo M; Pramstaller PP; van Duijn CM; Ferrucci L; Gambaro G; Deary IJ; Dunlop MG; Wilson JF; Gasparini P; Gyllensten U; Spector TD; Wright AF; Hayward C; Watkins H; Perola M; Bochud M; Kao WH; Caulfield M; Toniolo D; Völzke H; Gieger C; Köttgen A; Vitart V (2015)
      We tested for interactions between body mass index (BMI) and common genetic variants affecting serum urate levels, genome-wide, in up to 42569 participants. Both stratified genome-wide association (GWAS) analyses, in lean, ...
    • New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk 

      Dupuis J; Langenberg C; Prokopenko I; Saxena R; Soranzo N; Jackson AU; Wheeler E; Glazer NL; Bouatia-Naji N; Gloyn AL; Lindgren CM; Mägi R; Morris AP; Randall J; Johnson T; Elliott P; Rybin D; Thorleifsson G; Steinthorsdottir V; Henneman P; Grallert H; Dehghan A; Hottenga JJ; Franklin CS; Navarro P; Song K; Goel A; Perry JR; Egan JM; Lajunen T; Grarup N; Sparsø T; Doney A; Voight BF; Stringham HM; Li M; Kanoni S; Shrader P; Cavalcanti-Proença C; Kumari M; Qi L; Timpson NJ; Gieger C; Zabena C; Rocheleau G; Ingelsson E; An P; O'Connell J; Luan J; Elliott A; McCarroll SA; Payne F; Roccasecca RM; Pattou F; Sethupathy P; Ardlie K; Ariyurek Y; Balkau B; Barter P; Beilby JP; Ben-Shlomo Y; Benediktsson R; Bennett AJ; Bergmann S; Bochud M; Boerwinkle E; Bonnefond A; Bonnycastle LL; Borch-Johnsen K; Böttcher Y; Brunner E; Bumpstead SJ; Charpentier G; Chen YD; Chines P; Clarke R; Coin LJ; Cooper MN; Cornelis M; Crawford G; Crisponi L; Day IN; de Geus EJ; Delplanque J; Dina C; Erdos MR; Fedson AC; Fischer-Rosinsky A; Forouhi NG; Fox CS; Frants R; Franzosi MG; Galan P; Goodarzi MO; Graessler J; Groves CJ; Grundy S; Gwilliam R; Gyllensten U; Hadjadj S; Hallmans G; Hammond N; Han X; Hartikainen AL; Hassanali N; Hayward C; Heath SC; Hercberg S; Herder C; Hicks AA; Hillman DR; Hingorani AD; Hofman A; Hui J; Hung J; Isomaa B; Johnson PR; Jørgensen T; Jula A; Kaakinen M; Kaprio J; Kesaniemi YA; Kivimaki M; Knight B; Koskinen S; Kovacs P; Kyvik KO; Lathrop GM; Lawlor DA; Le Bacquer O; Lecoeur C; Li Y; Lyssenko V; Mahley R; Mangino M; Manning AK; Martínez-Larrad MT; McAteer JB; McCulloch LJ; McPherson R; Meisinger C; Melzer D; Meyre D; Mitchell BD; Morken MA; Mukherjee S; Naitza S; Narisu N; Neville MJ; Oostra BA; Orrù M; Pakyz R; Palmer CN; Paolisso G; Pattaro C; Pearson D; Peden JF; Pedersen NL; Perola M; Pfeiffer AF; Pichler I; Polasek O; Posthuma D; Potter SC; Pouta A; Province MA; Psaty BM; Rathmann W; Rayner NW; Rice K; Ripatti S; Rivadeneira F; Roden M; Rolandsson O; Sandbaek A; Sandhu M; Sanna S; Sayer AA; Scheet P; Scott LJ; Seedorf U; Sharp SJ; Shields B; Sigurethsson G; Sijbrands EJ; Silveira A; Simpson L; Singleton A; Smith NL; Sovio U; Swift A; Syddall H; Syvänen AC; Tanaka T; Thorand B; Tichet J; Tönjes A; Tuomi T; Uitterlinden AG; van Dijk KW; van Hoek M; Varma D; Visvikis-Siest S; Vitart V; Vogelzangs N; Waeber G; Wagner PJ; Walley A; Walters GB; Ward KL; Watkins H; Weedon MN; Wild SH; Willemsen G; Witteman JC; Yarnell JW; Zeggini E; Zelenika D; Zethelius B; Zhai G; Zhao JH; Zillikens MC; DIAGRAM Consortium; GIANT Consortium; Global BPgen Consortium; Borecki IB; Loos RJ; Meneton P; Magnusson PK; Nathan DM; Williams GH; Hattersley AT; Silander K; Salomaa V; Smith GD; Bornstein SR; Schwarz P; Spranger J; Karpe F; Shuldiner AR; Cooper C; Dedoussis GV; Serrano-Ríos M; Morris AD; Lind L; Palmer LJ; Hu FB; Franks PW; Ebrahim S; Marmot M; Kao WH; Pankow JS; Sampson MJ; Kuusisto J; Laakso M; Hansen T; Pedersen O; Pramstaller PP; Wichmann HE; Illig T; Rudan I; Wright AF; Stumvoll M; Campbell H; Wilson JF; Anders Hamsten on behalf of Procardis Consortium; MAGIC Investigators; Bergman RN; Buchanan TA; Collins FS; Mohlke KL; Tuomilehto J; Valle TT; Altshuler D; Rotter JI; Siscovick DS; Penninx BW; Boomsma DI; Deloukas P; Spector TD; Frayling TM; Ferrucci L; Kong A; Thorsteinsdottir U; Stefansson K; van Duijn CM; Aulchenko YS; Cao A; Scuteri A; Schlessinger D; Uda M; Ruokonen A; Jarvelin MR; Waterworth DM; Vollenweider P; Peltonen L; Mooser V; Abecasis GR; Wareham NJ; Sladek R; Froguel P; Watanabe RM; Meigs JB; Groop L; Boehnke M; McCarthy MI; Florez JC; Barroso I (2010)
      Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic traits, we performed meta-analyses of 21 genome-wide association studies informative for fasting glucose, fasting insulin and ...
    • NFAT5 and SLC4A10 Loci Associate with Plasma Osmolality 

      Böger CA; Gorski M; McMahon GM; Xu H; Chang YC; van der Most PJ; Navis G; Nolte IM; de Borst MH; Zhang W; Lehne B; Loh M; Tan ST; Boerwinkle E; Grams ME; Sekula P; Li M; Wilmot B; Moon JG; Scheet P; Cucca F; Xiao X; Lyytikäinen LP; Delgado G; Grammer TB; Kleber ME; Sedaghat S; Rivadeneira F; Corre T; Kutalik Z; Bergmann S; Nielson CM; Srikanth P; Teumer A; Müller-Nurasyid M; Brockhaus AC; Pfeufer A; Rathmann W; Peters A; Matsumoto M; de Andrade M; Atkinson EJ; Robinson-Cohen C; de Boer IH; Hwang SJ; Heid IM; Gögele M; Concas MP; Tanaka T; Bandinelli S; Nalls MA; Singleton A; Tajuddin SM; Adeyemo A; Zhou J; Doumatey A; McWeeney S; Murabito J; Franceschini N; Flessner M; Shlipak M; Wilson JG; Chen G; Rotimi CN; Zonderman AB; Evans MK; Ferrucci L; Devuyst O; Pirastu M; Shuldiner A; Hicks AA; Pramstaller PP; Kestenbaum B; Kardia SL; Turner ST; Study LC; Briske TE; Gieger C; Strauch K; Meisinger C; Meitinger T; Völker U; Nauck M; Völzke H; Vollenweider P; Bochud M; Waeber G; Kähönen M; Lehtimäki T; März W; Dehghan A; Franco OH; Uitterlinden AG; Hofman A; Taylor HA; Chambers JC; Kooner JS; Fox CS; Hitzemann R; Orwoll ES; Pattaro C; Schlessinger D; Köttgen A; Snieder H; Parsa A; Cohen DM (2017)
      Disorders of water balance, an excess or deficit of total body water relative to body electrolyte content, are common and ascertained by plasma hypo- or hypernatremia, respectively. We performed a two-stage genome-wide ...