Now showing items 1-14 of 14

    • Biological, clinical and population relevance of 95 loci for blood lipids 

      Teslovich TM; Musunuru K; Smith AV; Edmondson AC; Stylianou IM; Koseki M; Pirruccello JP; Ripatti S; Chasman DI; Willer CJ; Johansen CT; Fouchier SW; Isaacs A; Peloso GM; Barbalic M; Ricketts SL; Bis JC; Aulchenko YS; Thorleifsson G; Feitosa MF; Chambers J; Orho-Melander M; Melander O; Johnson T; Li X; Guo X; Li M; Shin Cho Y; Jin Go M; Jin Kim Y; Lee JY; Park T; Kim K; Sim X; Twee-Hee Ong R; Croteau-Chonka DC; Lange LA; Smith JD; Song K; Hua Zhao J; Yuan X; Luan J; Lamina C; Ziegler A; Zhang W; Zee RY; Wright AF; Witteman JC; Wilson JF; Willemsen G; Wichmann HE; Whitfield JB; Waterworth DM; Wareham NJ; Waeber G; Vollenweider P; Voight BF; Vitart V; Uitterlinden AG; Uda M; Tuomilehto J; Thompson JR; Tanaka T; Surakka I; Stringham HM; Spector TD; Soranzo N; Smit JH; Sinisalo J; Silander K; Sijbrands EJ; Scuteri A; Scott J; Schlessinger D; Sanna S; Salomaa V; Saharinen J; Sabatti C; Ruokonen A; Rudan I; Rose LM; Roberts R; Rieder M; Psaty BM; Pramstaller PP; Pichler I; Perola M; Penninx BW; Pedersen NL; Pattaro C; Parker AN; Pare G; Oostra BA; O'Donnell CJ; Nieminen MS; Nickerson DA; Montgomery GW; Meitinger T; McPherson R; McCarthy MI; McArdle W; Masson D; Martin NG; Marroni F; Mangino M; Magnusson PK; Lucas G; Luben R; Loos RJ; Lokki ML; Lettre G; Langenberg C; Launer LJ; Lakatta EG; Laaksonen R; Kyvik KO; Kronenberg F; König IR; Khaw KT; Kaprio J; Kaplan LM; Johansson A; Jarvelin MR; Janssens AC; Ingelsson E; Igl W; Kees Hovingh G; Hottenga JJ; Hofman A; Hicks AA; Hengstenberg C; Heid IM; Hayward C; Havulinna AS; Hastie ND; Harris TB; Haritunians T; Hall AS; Gyllensten U; Guiducci C; Groop LC; Gonzalez E; Gieger C; Freimer NB; Ferrucci L; Erdmann J; Elliott P; Ejebe KG; Döring A; Dominiczak AF; Demissie S; Deloukas P; de Geus EJ; de Faire U; Crawford G; Collins FS; Chen YD; Caulfield MJ; Campbell H; Burtt NP; Bonnycastle LL; Boomsma DI; Boekholdt SM; Bergman RN; Barroso I; Bandinelli S; Ballantyne CM; Assimes TL; Quertermous T; Altshuler D; Seielstad M; Wong TY; Tai ES; Feranil AB; Kuzawa CW; Adair LS; Taylor HA; Borecki IB; Gabriel SB; Wilson JG; Holm H; Thorsteinsdottir U; Gudnason V; Krauss RM; Mohlke KL; Ordovas JM; Munroe PB; Kooner JS; Tall AR; Hegele RA; Kastelein JJ; Schadt EE; Rotter JI; Boerwinkle E; Strachan DP; Mooser V; Stefansson K; Reilly MP; Samani NJ; Schunkert H; Cupples LA; Sandhu MS; Ridker PM; Rader DJ; van Duijn CM; Peltonen L; Abecasis GR; Boehnke M; Kathiresan S (2010)
      Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides are among the most important risk factors for coronary artery disease (CAD) and are ...
    • Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction 

      Sotoodehnia N; Isaacs A; de Bakker PI; Dörr M; Newton-Cheh C; Nolte IM; van der Harst P; Müller M; Eijgelsheim M; Alonso A; Hicks AA; Padmanabhan S; Hayward C; Smith AV; Polasek O; Giovannone S; Fu J; Magnani JW; Marciante KD; Pfeufer A; Gharib SA; Teumer A; Li M; Bis JC; Rivadeneira F; Aspelund T; Köttgen A; Johnson T; Rice K; Sie MP; Wang YA; Klopp N; Fuchsberger C; Wild SH; Mateo Leach I; Estrada K; Völker U; Wright AF; Asselbergs FW; Qu J; Chakravarti A; Sinner MF; Kors JA; Petersmann A; Harris TB; Soliman EZ; Munroe PB; Psaty BM; Oostra BA; Cupples LA; Perz S; de Boer RA; Uitterlinden AG; Völzke H; Spector TD; Liu FY; Boerwinkle E; Dominiczak AF; Rotter JI; van Herpen G; Levy D; Wichmann HE; van Gilst WH; Witteman JC; Kroemer HK; Kao WH; Heckbert SR; Meitinger T; Hofman A; Campbell H; Folsom AR; van Veldhuisen DJ; Schwienbacher C; O'Donnell CJ; Volpato CB; Caulfield MJ; Connell JM; Launer L; Lu X; Franke L; Fehrmann RS; te Meerman G; Groen HJ; Weersma RK; van den Berg LH; Wijmenga C; Ophoff RA; Navis G; Rudan I; Snieder H; Wilson JF; Pramstaller PP; Siscovick DS; Wang TJ; Gudnason V; van Duijn CM; Felix SB; Fishman GI; Jamshidi Y; Stricker BH; Samani NJ; Kääb S; Arking DE (2010)
      The QRS interval, from the beginning of the Q wave to the end of the S wave on an electrocardiogram, reflects ventricular depolarization and conduction time and is a risk factor for mortality, sudden death and heart failure. ...
    • Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits 

      Evangelou E; Warren HR; Mosen-Ansorena D; Mifsud B; Pazoki R; Gao H; Ntritsos G; Dimou N; Cabrera CP; Karaman I; Ng FL; Evangelou M; Witkowska K; Tzanis E; Hellwege JN; Giri A; Velez Edwards DR; Sun YV; Cho K; Gaziano JM; Wilson PWF; Tsao PS; Kovesdy CP; Esko T; Mägi R; Milani L; Almgren P; Boutin T; Debette S; Ding J; Giulianini F; Holliday EG; Jackson AU; Li-Gao R; Lin WY; Luan J; Mangino M; Oldmeadow C; Prins BP; Qian Y; Sargurupremraj M; Shah N; Surendran P; Thériault S; Verweij N; Willems SM; Zhao JH; Amouyel P; Connell J; de Mutsert R; Doney ASF; Farrall M; Menni C; Morris AD; Noordam R; Paré G; Poulter NR; Shields DC; Stanton A; Thom S; Abecasis G; Amin N; Arking DE; Ayers KL; Barbieri CM; Batini C; Bis JC; Blake T; Bochud M; Boehnke M; Boerwinkle E; Boomsma DI; Bottinger EP; Braund PS; Brumat M; Campbell A; Campbell H; Chakravarti A; Chambers JC; Chauhan G; Ciullo M; Cocca M; Collins F; Cordell HJ; Davies G; Borst MH; Geus EJ; Deary IJ; Deelen J; Del Greco M F; Demirkale CY; Dörr M; Ehret GB; Elosua R; Enroth S; Erzurumluoglu AM; Ferreira T; Frånberg M; Franco OH; Gandin I; Gasparini P; Giedraitis V; Gieger C; Girotto G; Goel A; Gow AJ; Gudnason V; Guo X; Gyllensten U; Hamsten A; Harris TB; Harris SE; Hartman CA; Havulinna AS; Hicks AA; Hofer E; Hofman A; Hottenga JJ; Huffman JE; Hwang SJ; Ingelsson E; James A; Jansen R; Jarvelin MR; Joehanes R; Johansson Å; Johnson AD; Joshi PK; Jousilahti P; Jukema JW; Jula A; Kähönen M; Kathiresan S; Keavney BD; Khaw KT; Knekt P; Knight J; Kolcic I; Kooner JS; Koskinen S; Kristiansson K; Kutalik Z; Laan M; Larson M; Launer LJ; Lehne B; Lehtimäki T; Liewald DCM; Lin L; Lind L; Lindgren CM; Liu Y; Loos RJF; Lopez LM; Lu Y; Lyytikäinen LP; Mahajan A; Mamasoula C; Marrugat J; Marten J; Milaneschi Y; Morgan A; Morris AP; Morrison AC; Munson PJ; Nalls MA; Nandakumar P; Nelson CP; Niiranen T; Nolte IM; Nutile T; Oldehinkel AJ; Oostra BA; O'Reilly PF; Org E; Padmanabhan S; Palmas W; Palotie A; Pattie A; Penninx BWJH; Perola M; Peters A; Polasek O; Pramstaller PP; Nguyen QT; Raitakari OT; Ren M; Rettig R; Rice K; Ridker PM; Ried JS; Riese H; Ripatti S; Robino A; Rose LM; Rotter JI; Rudan I; Ruggiero D; Saba Y; Sala CF; Salomaa V; Samani NJ; Sarin AP; Schmidt R; Schmidt H; Shrine N; Siscovick D; Smith AV; Snieder H; Sõber S; Sorice R; Starr JM; Stott DJ; Strachan DP; Strawbridge RJ; Sundström J; Swertz MA; Taylor KD; Teumer A; Tobin MD; Tomaszewski M; Toniolo D; Traglia M; Trompet S; Tuomilehto J; Tzourio C; Uitterlinden AG; Vaez A; van der Most PJ; van Duijn CM; Vergnaud AC; Verwoert GC; Vitart V; Völker U; Vollenweider P; Vuckovic D; Watkins H; Wild SH; Willemsen G; Wilson JF; Wright AF; Yao J; Zemunik T; Zhang W; Attia JR; Butterworth AS; Chasman DI; Conen D; Cucca F; Danesh J; Hayward C; Howson JMM; Laakso M; Lakatta EG; Langenberg C; Melander O; Mook-Kanamori DO; Palmer CNA; Risch L; Scott RA; Scott RJ; Sever P; Spector TD; van der Harst P; Wareham NJ; Zeggini E; Levy D; Munroe PB; Newton-Cheh C; Brown MJ; Metspalu A; Hung AM; O'Donnell CJ; Edwards TL; Million Veteran Program; Psaty BM; Tzoulaki I; Barnes MR; Wain LV; Elliott P; Caulfield MJ (2018)
      High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in ...
    • Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization 

      Arking DE; Pulit SL; Crotti L; van der Harst P; Munroe PB; Koopmann TT; Sotoodehnia N; Rossin EJ; Morley M; Wang X; Johnson AD; Lundby A; Gudbjartsson DF; Noseworthy PA; Eijgelsheim M; Bradford Y; Tarasov KV; Dörr M; Müller-Nurasyid M; Lahtinen AM; Nolte IM; Smith AV; Bis JC; Isaacs A; Newhouse SJ; Evans DS; Post WS; Waggott D; Lyytikäinen LP; Hicks AA; Eisele L; Ellinghaus D; Hayward C; Navarro P; Ulivi S; Tanaka T; Tester DJ; Chatel S; Gustafsson S; Kumari M; Morris RW; Naluai ÅT; Padmanabhan S; Kluttig A; Strohmer B; Panayiotou AG; Torres M; Knoflach M; Hubacek JA; Slowikowski K; Raychaudhuri S; Kumar RD; Harris TB; Launer LJ; Shuldiner AR; Alonso A; Bader JS; Ehret G; Huang H; Kao WH; Strait JB; Macfarlane PW; Brown M; Caulfield MJ; Samani NJ; Kronenberg F; Willeit J; CARe Consortium; COGENT Consortium; Smith JG; Greiser KH; Meyer Zu Schwabedissen H; Werdan K; Carella M; Zelante L; Heckbert SR; Psaty BM; Rotter JI; Kolcic I; Polašek O; Wright AF; Griffin M; Daly MJ; DCCT/EDIC; Arnar DO; Hólm H; Thorsteinsdottir U; eMERGE Consortium; Denny JC; Roden DM; Zuvich RL; Emilsson V; Plump AS; Larson MG; O'Donnell CJ; Yin X; Bobbo M; D'Adamo AP; Iorio A; Sinagra G; Carracedo A; Cummings SR; Nalls MA; Jula A; Kontula KK; Marjamaa A; Oikarinen L; Perola M; Porthan K; Erbel R; Hoffmann P; Jöckel KH; Kälsch H; Nöthen MM; HRGEN Consortium; den Hoed M; Loos RJ; Thelle DS; Gieger C; Meitinger T; Perz S; Peters A; Prucha H; Sinner MF; Waldenberger M; de Boer RA; Franke L; van der Vleuten PA; Beckmann BM; Martens E; Bardai A; Hofman N; Wilde AA; Behr ER; Dalageorgou C; Giudicessi JR; Medeiros-Domingo A; Barc J; Kyndt F; Probst V; Ghidoni A; Insolia R; Hamilton RM; Scherer SW; Brandimarto J; Margulies K; Moravec CE; Del Greco M F; Fuchsberger C; O'Connell JR; Lee WK; Watt GC; Campbell H; Wild SH; El Mokhtari NE; Frey N; Asselbergs FW; Mateo Leach I; Navis G; van den Berg MP; van Veldhuisen DJ; Kellis M; Krijthe BP; Franco OH; Hofman A; Kors JA; Uitterlinden AG; Witteman JC; Kedenko L; Lamina C; Oostra BA; Abecasis GR; Lakatta EG; Mulas A; Orrú M; Schlessinger D; Uda M; Markus MR; Völker U; Snieder H; Spector TD; Ärnlöv J; Lind L; Sundström J; Syvänen AC; Kivimaki M; Kähönen M; Mononen N; Raitakari OT; Viikari JS; Adamkova V; Kiechl S; Brion M; Nicolaides AN; Paulweber B; Haerting J; Dominiczak AF; Nyberg F; Whincup PH; Hingorani AD; Schott JJ; Bezzina CR; Ingelsson E; Ferrucci L; Gasparini P; Wilson JF; Rudan I; Franke A; Mühleisen TW; Pramstaller PP; Lehtimäki TJ; Paterson AD; Parsa A; Liu Y; van Duijn CM; Siscovick DS; Gudnason V; Jamshidi Y; Salomaa V; Felix SB; Sanna S; Ritchie MD; Stricker BH; Stefansson K; Boyer LA; Cappola TP; Olsen JV; Lage K; Schwartz PJ; Kääb S; Chakravarti A; Ackerman MJ; Pfeufer A; de Bakker PI; Newton-Cheh C (2014)
      The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate ...
    • Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk 

      International Consortium for Blood Pressure Genome-Wide Association Studies; Ehret GB; Munroe PB; Rice KM; Bochud M; Johnson AD; Chasman DI; Smith AV; Tobin MD; Verwoert GC; Hwang SJ; Pihur V; Vollenweider P; O'Reilly PF; Amin N; Bragg-Gresham JL; Teumer A; Glazer NL; Launer L; Zhao JH; Aulchenko Y; Heath S; Sõber S; Parsa A; Luan J; Arora P; Dehghan A; Zhang F; Lucas G; Hicks AA; Jackson AU; Peden JF; Tanaka T; Wild SH; Rudan I; Igl W; Milaneschi Y; Parker AN; Fava C; Chambers JC; Fox ER; Kumari M; Go MJ; van der Harst P; Kao WH; Sjögren M; Vinay DG; Alexander M; Tabara Y; Shaw-Hawkins S; Whincup PH; Liu Y; Shi G; Kuusisto J; Tayo B; Seielstad M; Sim X; Nguyen KD; Lehtimäki T; Matullo G; Wu Y; Gaunt TR; Onland-Moret NC; Cooper MN; Platou CG; Org E; Hardy R; Dahgam S; Palmen J; Vitart V; Braund PS; Kuznetsova T; Uiterwaal CS; Adeyemo A; Palmas W; Campbell H; Ludwig B; Tomaszewski M; Tzoulaki I; Palmer ND; CARDIoGRAM Consortium; CKDGen Consortium; KidneyGen Consortium; EchoGen consortium; CHARGE-HF consortium; Aspelund T; Garcia M; Chang YP; O'Connell JR; Steinle NI; Grobbee DE; Arking DE; Kardia SL; Morrison AC; Hernandez D; Najjar S; McArdle WL; Hadley D; Brown MJ; Connell JM; Hingorani AD; Day IN; Lawlor DA; Beilby JP; Lawrence RW; Clarke R; Hopewell JC; Ongen H; Dreisbach AW; Li Y; Young JH; Bis JC; Kähönen M; Viikari J; Adair LS; Lee NR; Chen MH; Olden M; Pattaro C; Bolton JA; Köttgen A; Bergmann S; Mooser V; Chaturvedi N; Frayling TM; Islam M; Jafar TH; Erdmann J; Kulkarni SR; Bornstein SR; Grässler J; Groop L; Voight BF; Kettunen J; Howard P; Taylor A; Guarrera S; Ricceri F; Emilsson V; Plump A; Barroso I; Khaw KT; Weder AB; Hunt SC; Sun YV; Bergman RN; Collins FS; Bonnycastle LL; Scott LJ; Stringham HM; Peltonen L; Perola M; Vartiainen E; Brand SM; Staessen JA; Wang TJ; Burton PR; Soler Artigas M; Dong Y; Snieder H; Wang X; Zhu H; Lohman KK; Rudock ME; Heckbert SR; Smith NL; Wiggins KL; Doumatey A; Shriner D; Veldre G; Viigimaa M; Kinra S; Prabhakaran D; Tripathy V; Langefeld CD; Rosengren A; Thelle DS; Corsi AM; Singleton A; Forrester T; Hilton G; McKenzie CA; Salako T; Iwai N; Kita Y; Ogihara T; Ohkubo T; Okamura T; Ueshima H; Umemura S; Eyheramendy S; Meitinger T; Wichmann HE; Cho YS; Kim HL; Lee JY; Scott J; Sehmi JS; Zhang W; Hedblad B; Nilsson P; Smith GD; Wong A; Narisu N; Stancáková A; Raffel LJ; Yao J; Kathiresan S; O'Donnell CJ; Schwartz SM; Ikram MA; Longstreth WT; Mosley TH; Seshadri S; Shrine NR; Wain LV; Morken MA; Swift AJ; Laitinen J; Prokopenko I; Zitting P; Cooper JA; Humphries SE; Danesh J; Rasheed A; Goel A; Hamsten A; Watkins H; Bakker SJ; van Gilst WH; Janipalli CS; Mani KR; Yajnik CS; Hofman A; Mattace-Raso FU; Oostra BA; Demirkan A; Isaacs A; Rivadeneira F; Lakatta EG; Orru M; Scuteri A; Ala-Korpela M; Kangas AJ; Lyytikäinen LP; Soininen P; Tukiainen T; Würtz P; Ong RT; Dörr M; Kroemer HK; Völker U; Völzke H; Galan P; Hercberg S; Lathrop M; Zelenika D; Deloukas P; Mangino M; Spector TD; Zhai G; Meschia JF; Nalls MA; Sharma P; Terzic J; Kumar MV; Denniff M; Zukowska-Szczechowska E; Wagenknecht LE; Fowkes FG; Charchar FJ; Schwarz PE; Hayward C; Guo X; Rotimi C; Bots ML; Brand E; Samani NJ; Polasek O; Talmud PJ; Nyberg F; Kuh D; Laan M; Hveem K; Palmer LJ; van der Schouw YT; Casas JP; Mohlke KL; Vineis P; Raitakari O; Ganesh SK; Wong TY; Tai ES; Cooper RS; Laakso M; Rao DC; Harris TB; Morris RW; Dominiczak AF; Kivimaki M; Marmot MG; Miki T; Saleheen D; Chandak GR; Coresh J; Navis G; Salomaa V; Han BG; Zhu X; Kooner JS; Melander O; Ridker PM; Bandinelli S; Gyllensten UB; Wright AF; Wilson JF; Ferrucci L; Farrall M; Tuomilehto J; Pramstaller PP; Elosua R; Soranzo N; Sijbrands EJ; Altshuler D; Loos RJ; Shuldiner AR; Gieger C; Meneton P; Uitterlinden AG; Wareham NJ; Gudnason V; Rotter JI; Rettig R; Uda M; Strachan DP; Witteman JC; Hartikainen AL; Beckmann JS; Boerwinkle E; Vasan RS; Boehnke M; Larson MG; Järvelin MR; Psaty BM; Abecasis GR; Chakravarti A; Elliott P; van Duijn CM; Newton-Cheh C; Levy D; Caulfield MJ; Johnson T (2011)
      Blood pressure is a heritable trait influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm Hg systolic blood pressure or  ≥90 mm Hg ...
    • Genome-wide association analysis identifies multiple loci related to resting heart rate 

      Eijgelsheim M; Newton-Cheh C; Sotoodehnia N; de Bakker PI; Müller M; Morrison AC; Smith AV; Isaacs A; Sanna S; Dörr M; Navarro P; Fuchsberger C; Nolte IM; de Geus EJ; Estrada K; Hwang SJ; Bis JC; Rückert IM; Alonso A; Launer LJ; Hottenga JJ; Rivadeneira F; Noseworthy PA; Rice KM; Perz S; Arking DE; Spector TD; Kors JA; Aulchenko YS; Tarasov KV; Homuth G; Wild SH; Marroni F; Gieger C; Licht CM; Prineas RJ; Hofman A; Rotter JI; Hicks AA; Ernst F; Najjar SS; Wright AF; Peters A; Fox ER; Oostra BA; Kroemer HK; Couper D; Völzke H; Campbell H; Meitinger T; Uda M; Witteman JC; Psaty BM; Wichmann HE; Harris TB; Kääb S; Siscovick DS; Jamshidi Y; Uitterlinden AG; Folsom AR; Larson MG; Wilson JF; Penninx BW; Snieder H; Pramstaller PP; van Duijn CM; Lakatta EG; Felix SB; Gudnason V; Pfeufer A; Heckbert SR; Stricker BH; Boerwinkle E; O'Donnell CJ (2010)
      Higher resting heart rate is associated with increased cardiovascular disease and mortality risk. Though heritable factors play a substantial role in population variation, little is known about specific genetic determinants. ...
    • Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits 

      Speliotes EK; Yerges-Armstrong LM; Wu J; Hernaez R; Kim LJ; Palmer CD; Gudnason V; Eiriksdottir G; Garcia ME; Launer LJ; Nalls MA; Clark JM; Mitchell BD; Shuldiner AR; Butler JL; Tomas M; Hoffmann U; Hwang SJ; Massaro JM; O'Donnell CJ; Sahani DV; Salomaa V; Schadt EE; Schwartz SM; Siscovick DS; NASH CRN; GIANT Consortium; MAGIC Investigators; Voight BF; Carr JJ; Feitosa MF; Harris TB; Fox CS; Smith AV; Kao WH; Hirschhorn JN; Borecki IB; GOLD Consortium (2011)
      Nonalcoholic fatty liver disease (NAFLD) clusters in families, but the only known common genetic variants influencing risk are near PNPLA3. We sought to identify additional genetic variants influencing NAFLD using genome-wide ...
    • Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma 

      Chambers JC; Zhang W; Sehmi J; Li X; Wass MN; van der Harst P; Holm H; Sanna S; Kavousi M; Baumeister SE; Coin LJ; Deng G; Gieger C; Heard-Costa NL; Hottenga JJ; Kühnel B; Kumar V; Lagou V; Liang L; Luan J; Vidal PM; Mateo Leach I; O'Reilly PF; Peden JF; Rahmioglu N; Soininen P; Speliotes EK; Yuan X; Thorleifsson G; Alizadeh BZ; Atwood LD; Borecki IB; Brown MJ; Charoen P; Cucca F; Das D; de Geus EJ; Dixon AL; Döring A; Ehret G; Eyjolfsson GI; Farrall M; Forouhi NG; Friedrich N; Goessling W; Gudbjartsson DF; Harris TB; Hartikainen AL; Heath S; Hirschfield GM; Hofman A; Homuth G; Hyppönen E; Janssen HL; Johnson T; Kangas AJ; Kema IP; Kühn JP; Lai S; Lathrop M; Lerch MM; Li Y; Liang TJ; Lin JP; Loos RJ; Martin NG; Moffatt MF; Montgomery GW; Munroe PB; Musunuru K; Nakamura Y; O'Donnell CJ; Olafsson I; Penninx BW; Pouta A; Prins BP; Prokopenko I; Puls R; Ruokonen A; Savolainen MJ; Schlessinger D; Schouten JN; Seedorf U; Sen-Chowdhry S; Siminovitch KA; Smit JH; Spector TD; Tan W; Teslovich TM; Tukiainen T; Uitterlinden AG; van der Klauw MM; Vasan RS; Wallace C; Wallaschofski H; Wichmann HE; Willemsen G; Würtz P; Xu C; Yerges-Armstrong LM; Alcohol Genome-wide Association (AlcGen) Consortium; DIAGRAM Consortium; Genetic Investigation of Anthropometric Traits (GIANT) Consortium; Global Lipids Genetics Consortium; Genetics of Liver Disease (GOLD) Consortium; International Consortium for Blood Pressure (ICBP-GWAS); MAGIC Consortium; Abecasis GR; Ahmadi KR; Boomsma DI; Caulfield M; Cookson WO; van Duijn CM; Froguel P; Matsuda K; McCarthy MI; Meisinger C; Mooser V; Pietiläinen KH; Schumann G; Snieder H; Sternberg MJ; Stolk RP; Thomas HC; Thorsteinsdottir U; Uda M; Waeber G; Wareham NJ; Waterworth DM; Watkins H; Whitfield JB; Witteman JC; Wolffenbuttel BH; Fox CS; Ala-Korpela M; Stefansson K; Vollenweider P; Völzke H; Schadt EE; Scott J; Järvelin MR; Elliott P; Kooner JS (2011)
      Concentrations of liver enzymes in plasma are widely used as indicators of liver disease. We carried out a genome-wide association study in 61,089 individuals, identifying 42 loci associated with concentrations of liver ...
    • Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations 

      Demirkan A; van Duijn CM; Ugocsai P; Isaacs A; Pramstaller PP; Liebisch G; Wilson JF; Johansson Å; Rudan I; Aulchenko YS; Kirichenko AV; Janssens AC; Jansen RC; Gnewuch C; Domingues FS; Pattaro C; Wild SH; Jonasson I; Polasek O; Zorkoltseva IV; Hofman A; Karssen LC; Struchalin M; Floyd J; Igl W; Biloglav Z; Broer L; Pfeufer A; Pichler I; Campbell S; Zaboli G; Kolcic I; Rivadeneira F; Huffman J; Hastie ND; Uitterlinden A; Franke L; Franklin CS; Vitart V; DIAGRAM Consortium; Nelson CP; Preuss M; CARDIoGRAM Consortium; Bis JC; O'Donnell CJ; Franceschini N; CHARGE Consortium; Witteman JC; Axenovich T; Oostra BA; Meitinger T; Hicks AA; Hayward C; Wright AF; Gyllensten U; Campbell H; Schmitz G; EUROSPAN Consortium (2012)
      Phospho- and sphingolipids are crucial cellular and intracellular compounds. These lipids are required for active transport, a number of enzymatic processes, membrane formation, and cell signalling. Disruption of their ...
    • Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure 

      Wain LV; Verwoert GC; O'Reilly PF; Shi G; Johnson T; Johnson AD; Bochud M; Rice KM; Henneman P; Smith AV; Ehret GB; Amin N; Larson MG; Mooser V; Hadley D; Dörr M; Bis JC; Aspelund T; Esko T; Janssens AC; Zhao JH; Heath S; Laan M; Fu J; Pistis G; Luan J; Arora P; Lucas G; Pirastu N; Pichler I; Jackson AU; Webster RJ; Zhang F; Peden JF; Schmidt H; Tanaka T; Campbell H; Igl W; Milaneschi Y; Hottenga JJ; Vitart V; Chasman DI; Trompet S; Bragg-Gresham JL; Alizadeh BZ; Chambers JC; Guo X; Lehtimäki T; Kühnel B; Lopez LM; Polašek O; Boban M; Nelson CP; Morrison AC; Pihur V; Ganesh SK; Hofman A; Kundu S; Mattace-Raso FU; Rivadeneira F; Sijbrands EJ; Uitterlinden AG; Hwang SJ; Vasan RS; Wang TJ; Bergmann S; Vollenweider P; Waeber G; Laitinen J; Pouta A; Zitting P; McArdle WL; Kroemer HK; Völker U; Völzke H; Glazer NL; Taylor KD; Harris TB; Alavere H; Haller T; Keis A; Tammesoo ML; Aulchenko Y; Barroso I; Khaw KT; Galan P; Hercberg S; Lathrop M; Eyheramendy S; Org E; Sõber S; Lu X; Nolte IM; Penninx BW; Corre T; Masciullo C; Sala C; Groop L; Voight BF; Melander O; O'Donnell CJ; Salomaa V; D'Adamo AP; Fabretto A; Faletra F; Ulivi S; Del Greco M F; Facheris M; Collins FS; Bergman RN; Beilby JP; Hung J; Musk AW; Mangino M; Shin SY; Soranzo N; Watkins H; Goel A; Hamsten A; Gider P; Loitfelder M; Zeginigg M; Hernandez D; Najjar SS; Navarro P; Wild SH; Corsi AM; Singleton A; de Geus EJ; Willemsen G; Parker AN; Rose LM; Buckley B; Stott D; Orru M; Uda M; LifeLines Cohort Study; van der Klauw MM; Zhang W; Li X; Scott J; Chen YD; Burke GL; Kähönen M; Viikari J; Döring A; Meitinger T; Davies G; Starr JM; Emilsson V; Plump A; Lindeman JH; Hoen PA; König IR; EchoGen consortium; Felix JF; Clarke R; Hopewell JC; Ongen H; Breteler M; Debette S; DeStefano AL; Fornage M; AortaGen Consortium; Mitchell GF; CHARGE Consortium Heart Failure Working Group; Smith NL; KidneyGen consortium; Holm H; Stefansson K; Thorleifsson G; Thorsteinsdottir U; CKDGen Consortium; Cardiogenics consortium; CARDIoGRAM Consortium; Samani NJ; Preuss M; Rudan I; Hayward C; Deary IJ; Wichmann HE; Raitakari OT; Palmas W; Kooner JS; Stolk RP; Jukema JW; Wright AF; Boomsma DI; Bandinelli S; Gyllensten UB; Wilson JF; Ferrucci L; Schmidt R; Farrall M; Spector TD; Palmer LJ; Tuomilehto J; Pfeufer A; Gasparini P; Siscovick D; Altshuler D; Loos RJ; Toniolo D; Snieder H; Gieger C; Meneton P; Wareham NJ; Oostra BA; Metspalu A; Launer L; Rettig R; Strachan DP; Beckmann JS; Witteman JC; Erdmann J; van Dijk KW; Boerwinkle E; Boehnke M; Ridker PM; Jarvelin MR; Chakravarti A; Abecasis GR; Gudnason V; Newton-Cheh C; Levy D; Munroe PB; Psaty BM; Caulfield MJ; Rao DC; Tobin MD; Elliott P; van Duijn CM (2011)
      Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans. We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure ...
    • Hundreds of variants clustered in genomic loci and biological pathways affect human height 

      Lango Allen H; Estrada K; Lettre G; Berndt SI; Weedon MN; Rivadeneira F; Willer CJ; Jackson AU; Vedantam S; Raychaudhuri S; Ferreira T; Wood AR; Weyant RJ; Segrè AV; Speliotes EK; Wheeler E; Soranzo N; Park JH; Yang J; Gudbjartsson D; Heard-Costa NL; Randall JC; Qi L; Vernon Smith A; Mägi R; Pastinen T; Liang L; Heid IM; Luan J; Thorleifsson G; Winkler TW; Goddard ME; Sin Lo K; Palmer C; Workalemahu T; Aulchenko YS; Johansson A; Zillikens MC; Feitosa MF; Esko T; Johnson T; Ketkar S; Kraft P; Mangino M; Prokopenko I; Absher D; Albrecht E; Ernst F; Glazer NL; Hayward C; Hottenga JJ; Jacobs KB; Knowles JW; Kutalik Z; Monda KL; Polasek O; Preuss M; Rayner NW; Robertson NR; Steinthorsdottir V; Tyrer JP; Voight BF; Wiklund F; Xu J; Zhao JH; Nyholt DR; Pellikka N; Perola M; Perry JR; Surakka I; Tammesoo ML; Altmaier EL; Amin N; Aspelund T; Bhangale T; Boucher G; Chasman DI; Chen C; Coin L; Cooper MN; Dixon AL; Gibson Q; Grundberg E; Hao K; Juhani Junttila M; Kaplan LM; Kettunen J; König IR; Kwan T; Lawrence RW; Levinson DF; Lorentzon M; McKnight B; Morris AP; Müller M; Suh Ngwa J; Purcell S; Rafelt S; Salem RM; Salvi E; Sanna S; Shi J; Sovio U; Thompson JR; Turchin MC; Vandenput L; Verlaan DJ; Vitart V; White CC; Ziegler A; Almgren P; Balmforth AJ; Campbell H; Citterio L; De Grandi A; Dominiczak A; Duan J; Elliott P; Elosua R; Eriksson JG; Freimer NB; Geus EJ; Glorioso N; Haiqing S; Hartikainen AL; Havulinna AS; Hicks AA; Hui J; Igl W; Illig T; Jula A; Kajantie E; Kilpeläinen TO; Koiranen M; Kolcic I; Koskinen S; Kovacs P; Laitinen J; Liu J; Lokki ML; Marusic A; Maschio A; Meitinger T; Mulas A; Paré G; Parker AN; Peden JF; Petersmann A; Pichler I; Pietiläinen KH; Pouta A; Ridderstråle M; Rotter JI; Sambrook JG; Sanders AR; Schmidt CO; Sinisalo J; Smit JH; Stringham HM; Bragi Walters G; Widen E; Wild SH; Willemsen G; Zagato L; Zgaga L; Zitting P; Alavere H; Farrall M; McArdle WL; Nelis M; Peters MJ; Ripatti S; van Meurs JB; Aben KK; Ardlie KG; Beckmann JS; Beilby JP; Bergman RN; Bergmann S; Collins FS; Cusi D; den Heijer M; Eiriksdottir G; Gejman PV; Hall AS; Hamsten A; Huikuri HV; Iribarren C; Kähönen M; Kaprio J; Kathiresan S; Kiemeney L; Kocher T; Launer LJ; Lehtimäki T; Melander O; Mosley TH; Musk AW; Nieminen MS; O'Donnell CJ; Ohlsson C; Oostra B; Palmer LJ; Raitakari O; Ridker PM; Rioux JD; Rissanen A; Rivolta C; Schunkert H; Shuldiner AR; Siscovick DS; Stumvoll M; Tönjes A; Tuomilehto J; van Ommen GJ; Viikari J; Heath AC; Martin NG; Montgomery GW; Province MA; Kayser M; Arnold AM; Atwood LD; Boerwinkle E; Chanock SJ; Deloukas P; Gieger C; Grönberg H; Hall P; Hattersley AT; Hengstenberg C; Hoffman W; Lathrop GM; Salomaa V; Schreiber S; Uda M; Waterworth D; Wright AF; Assimes TL; Barroso I; Hofman A; Mohlke KL; Boomsma DI; Caulfield MJ; Cupples LA; Erdmann J; Fox CS; Gudnason V; Gyllensten U; Harris TB; Hayes RB; Jarvelin MR; Mooser V; Munroe PB; Ouwehand WH; Penninx BW; Pramstaller PP; Quertermous T; Rudan I; Samani NJ; Spector TD; Völzke H; Watkins H; Wilson JF; Groop LC; Haritunians T; Hu FB; Kaplan RC; Metspalu A; North KE; Schlessinger D; Wareham NJ; Hunter DJ; O'Connell JR; Strachan DP; Wichmann HE; Borecki IB; van Duijn CM; Schadt EE; Thorsteinsdottir U; Peltonen L; Uitterlinden AG; Visscher PM; Chatterjee N; Loos RJ; Boehnke M; McCarthy MI; Ingelsson E; Lindgren CM; Abecasis GR; Stefansson K; Frayling TM; Hirschhorn JN (2010)
      Most common human traits and diseases have a polygenic pattern of inheritance: DNA sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA) studies have identified more than 600 variants ...
    • Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders 

      den Hoed M; Eijgelsheim M; Esko T; Brundel BJ; Peal DS; Evans DM; Nolte IM; Segrè AV; Holm H; Handsaker RE; Westra HJ; Johnson T; Isaacs A; Yang J; Lundby A; Zhao JH; Kim YJ; Go MJ; Almgren P; Bochud M; Boucher G; Cornelis MC; Gudbjartsson D; Hadley D; van der Harst P; Hayward C; den Heijer M; Igl W; Jackson AU; Kutalik Z; Luan J; Kemp JP; Kristiansson K; Ladenvall C; Lorentzon M; Montasser ME; Njajou OT; O'Reilly PF; Padmanabhan S; St Pourcain B; Rankinen T; Salo P; Tanaka T; Timpson NJ; Vitart V; Waite L; Wheeler W; Zhang W; Draisma HH; Feitosa MF; Kerr KF; Lind PA; Mihailov E; Onland-Moret NC; Song C; Weedon MN; Xie W; Yengo L; Absher D; Albert CM; Alonso A; Arking DE; de Bakker PI; Balkau B; Barlassina C; Benaglio P; Bis JC; Bouatia-Naji N; Brage S; Chanock SJ; Chines PS; Chung M; Darbar D; Dina C; Dörr M; Elliott P; Felix SB; Fischer K; Fuchsberger C; de Geus EJ; Goyette P; Gudnason V; Harris TB; Hartikainen AL; Havulinna AS; Heckbert SR; Hicks AA; Hofman A; Holewijn S; Hoogstra-Berends F; Hottenga JJ; Jensen MK; Johansson A; Junttila J; Kääb S; Kanon B; Ketkar S; Khaw KT; Knowles JW; Kooner AS; Kors JA; Kumari M; Milani L; Laiho P; Lakatta EG; Langenberg C; Leusink M; Liu Y; Luben RN; Lunetta KL; Lynch SN; Markus MR; Marques-Vidal P; Mateo Leach I; McArdle WL; McCarroll SA; Medland SE; Miller KA; Montgomery GW; Morrison AC; Müller-Nurasyid M; Navarro P; Nelis M; O'Connell JR; O'Donnell CJ; Ong KK; Newman AB; Peters A; Polasek O; Pouta A; Pramstaller PP; Psaty BM; Rao DC; Ring SM; Rossin EJ; Rudan D; Sanna S; Scott RA; Sehmi JS; Sharp S; Shin JT; Singleton AB; Smith AV; Soranzo N; Spector TD; Stewart C; Stringham HM; Tarasov KV; Uitterlinden AG; Vandenput L; Hwang SJ; Whitfield JB; Wijmenga C; Wild SH; Willemsen G; Wilson JF; Witteman JC; Wong A; Wong Q; Jamshidi Y; Zitting P; Boer JM; Boomsma DI; Borecki IB; van Duijn CM; Ekelund U; Forouhi NG; Froguel P; Hingorani A; Ingelsson E; Kivimaki M; Kronmal RA; Kuh D; Lind L; Martin NG; Oostra BA; Pedersen NL; Quertermous T; Rotter JI; van der Schouw YT; Verschuren WM; Walker M; Albanes D; Arnar DO; Assimes TL; Bandinelli S; Boehnke M; de Boer RA; Bouchard C; Caulfield WL; Chambers JC; Curhan G; Cusi D; Eriksson J; Ferrucci L; van Gilst WH; Glorioso N; de Graaf J; Groop L; Gyllensten U; Hsueh WC; Hu FB; Huikuri HV; Hunter DJ; Iribarren C; Isomaa B; Jarvelin MR; Jula A; Kähönen M; Kiemeney LA; van der Klauw MM; Kooner JS; Kraft P; Iacoviello L; Lehtimäki T; Lokki ML; Mitchell BD; Navis G; Nieminen MS; Ohlsson C; Poulter NR; Qi L; Raitakari OT; Rimm EB; Rioux JD; Rizzi F; Rudan I; Salomaa V; Sever PS; Shields DC; Shuldiner AR; Sinisalo J; Stanton AV; Stolk RP; Strachan DP; Tardif JC; Thorsteinsdottir U; Tuomilehto J; van Veldhuisen DJ; Virtamo J; Viikari J; Vollenweider P; Waeber G; Widen E; Cho YS; Olsen JV; Visscher PM; Willer C; Franke L; Global BPgen Consortium; CARDIoGRAM Consortium; Erdmann J; Thompson JR; PR GWAS Consortium; Pfeufer A; QRS GWAS Consortium; Sotoodehnia N; QT-IGC Consortium; Newton-Cheh C; CHARGE-AF Consortium; Ellinor PT; Stricker BH; Metspalu A; Perola M; Beckmann JS; Smith GD; Stefansson K; Wareham NJ; Munroe PB; Sibon OC; Milan DJ; Snieder H; Samani NJ; Loos RJ (2013)
      Elevated resting heart rate is associated with greater risk of cardiovascular disease and mortality. In a 2-stage meta-analysis of genome-wide association studies in up to 181,171 individuals, we identified 14 new loci ...
    • Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci 

      Liu C; Kraja AT; Smith JA; Brody JA; Franceschini N; Bis JC; Rice K; Morrison AC; Lu Y; Weiss S; Guo X; Palmas W; Martin LW; Chen YI; Surendran P; Drenos F; Cook JP; Auer PL; Chu AY; Giri A; Zhao W; Jakobsdottir J; Lin LA; Stafford JM; Amin N; Mei H; Yao J; Voorman A; CHD Exome+ Consortium; ExomeBP Consortium; GoT2DGenes Consortium; T2D-GENES Consortium; Larson MG; Grove ML; Smith AV; Hwang SJ; Chen H; Huan T; Kosova G; Stitziel NO; Kathiresan S; Samani N; Schunkert H; Deloukas P; Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia; Li M; Fuchsberger C; Pattaro C; Gorski M; CKDGen Consortium; Kooperberg C; Papanicolaou GJ; Rossouw JE; Faul JD; Kardia SL; Bouchard C; Raffel LJ; Uitterlinden AG; Franco OH; Vasan RS; O'Donnell CJ; Taylor KD; Liu K; Bottinger EP; Gottesman O; Daw EW; Giulianini F; Ganesh S; Salfati E; Harris TB; Launer LJ; Dörr M; Felix SB; Rettig R; Völzke H; Kim E; Lee WJ; Lee IT; Sheu WH; Tsosie KS; Edwards DR; Liu Y; Correa A; Weir DR; Völker U; Ridker PM; Boerwinkle E; Gudnason V; Reiner AP; van Duijn CM; Borecki IB; Edwards TL; Chakravarti A; Rotter JI; Psaty BM; Loos RJ; Fornage M; Ehret GB; Newton-Cheh C; Levy D; Chasman DI (2016)
      Meta-analyses of association results for blood pressure using exome-centric single-variant and gene-based tests identified 31 new loci in a discovery stage among 146,562 individuals, with follow-up and meta-analysis in ...
    • NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium 

      Heard-Costa NL; Zillikens MC; Monda KL; Johansson A; Harris TB; Fu M; Haritunians T; Feitosa MF; Aspelund T; Eiriksdottir G; Garcia M; Launer LJ; Smith AV; Mitchell BD; McArdle PF; Shuldiner AR; Bielinski SJ; Boerwinkle E; Brancati F; Demerath EW; Pankow JS; Arnold AM; Chen YD; Glazer NL; McKnight B; Psaty BM; Rotter JI; Amin N; Campbell H; Gyllensten U; Pattaro C; Pramstaller PP; Rudan I; Struchalin M; Vitart V; Gao X; Kraja A; Province MA; Zhang Q; Atwood LD; Dupuis J; Hirschhorn JN; Jaquish CE; O'Donnell CJ; Vasan RS; White CC; Aulchenko YS; Estrada K; Hofman A; Rivadeneira F; Uitterlinden AG; Witteman JC; Oostra BA; Kaplan RC; Gudnason V; O'Connell JR; Borecki IB; van Duijn CM; Cupples LA; Fox CS; North KE (2009)
      Central abdominal fat is a strong risk factor for diabetes and cardiovascular disease. To identify common variants influencing central abdominal fat, we conducted a two-stage genome-wide association analysis for waist ...