Now showing items 1-3 of 3

    • The genetic architecture of type 2 diabetes 

      Fuchsberger C; Flannick J; Teslovich TM; Mahajan A; Agarwala V; Gaulton KJ; Ma C; Fontanillas P; Moutsianas L; McCarthy DJ; Rivas MA; Perry JR; Sim X; Blackwell TW; Robertson NR; Rayner NW; Cingolani P; Locke AE; Fernandez Tajes J; Highland HM; Dupuis J; Chines PS; Lindgren CM; Hartl C; Jackson AU; Chen H; Huyghe JR; van de Bunt M; Pearson RD; Kumar A; Müller-Nurasyid M; Grarup N; Stringham HM; Gamazon ER; Lee J; Chen Y; Scott RA; Below JE; Chen P; Huang J; Go MJ; Stitzel ML; Pasko D; Parker SC; Varga TV; Green T; Beer NL; Day-Williams AG; Ferreira T; Fingerlin T; Horikoshi M; Hu C; Huh I; Ikram MK; Kim BJ; Kim Y; Kim YJ; Kwon MS; Lee S; Lin KH; Maxwell TJ; Nagai Y; Wang X; Welch RP; Yoon J; Zhang W; Barzilai N; Voight BF; Han BG; Jenkinson CP; Kuulasmaa T; Kuusisto J; Manning A; Ng MC; Palmer ND; Balkau B; Stancáková A; Abboud HE; Boeing H; Giedraitis V; Prabhakaran D; Gottesman O; Scott J; Carey J; Kwan P; Grant G; Smith JD; Neale BM; Purcell S; Butterworth AS; Howson JM; Lee HM; Lu Y; Kwak SH; Zhao W; Danesh J; Lam VK; Park KS; Saleheen D; So WY; Tam CH; Afzal U; Aguilar D; Arya R; Aung T; Chan E; Navarro C; Cheng CY; Palli D; Correa A; Curran JE; Rybin D; Farook VS; Fowler SP; Freedman BI; Griswold M; Hale DE; Hicks PJ; Khor CC; Kumar S; Lehne B; Thuillier D; Lim WY; Liu J; van der Schouw YT; Loh M; Musani SK; Puppala S; Scott WR; Yengo L; Tan ST; Taylor HA Jr; Thameem F; Wilson G Sr; Wong TY; Njølstad PR; Levy JC; Mangino M; Bonnycastle LL; Schwarzmayr T; Fadista J; Surdulescu GL; Herder C; Groves CJ; Wieland T; Bork-Jensen J; Brandslund I; Christensen C; Koistinen HA; Doney AS; Kinnunen L; Esko T; Farmer AJ; Hakaste L; Hodgkiss D; Kravic J; Lyssenko V; Hollensted M; Jørgensen ME; Jørgensen T; Ladenvall C; Justesen JM; Käräjämäki A; Kriebel J; Rathmann W; Lannfelt L; Lauritzen T; Narisu N; Linneberg A; Melander O; Milani L; Neville M; Orho-Melander M; Qi L; Qi Q; Roden M; Rolandsson O; Swift A; Rosengren AH; Stirrups K; Wood AR; Mihailov E; Blancher C; Carneiro MO; Maguire J; Poplin R; Shakir K; Fennell T; DePristo M; Hrabé de Angelis M; Deloukas P; Gjesing AP; Jun G; Nilsson P; Murphy J; Onofrio R; Thorand B; Hansen T; Meisinger C; Hu FB; Isomaa B; Karpe F; Liang L; Peters A; Huth C; O'Rahilly SP; Palmer CN; Pedersen O; Rauramaa R; Tuomilehto J; Salomaa V; Watanabe RM; Syvänen AC; Bergman RN; Bharadwaj D; Bottinger EP; Cho YS; Chandak GR; Chan JC; Chia KS; Daly MJ; Ebrahim SB; Langenberg C; Elliott P; Jablonski KA; Lehman DM; Jia W; Ma RC; Pollin TI; Sandhu M; Tandon N; Froguel P; Barroso I; Teo YY; Zeggini E; Loos RJ; Small KS; Ried JS; DeFronzo RA; Grallert H; Glaser B; Metspalu A; Wareham NJ; Walker M; Banks E; Gieger C; Ingelsson E; Im HK; Illig T; Franks PW; Buck G; Trakalo J; Buck D; Prokopenko I; Mägi R; Lind L; Farjoun Y; Owen KR; Gloyn AL; Strauch K; Tuomi T; Kooner JS; Lee JY; Park T; Donnelly P; Morris AD; Hattersley AT; Bowden DW; Collins FS; Atzmon G; Chambers JC; Spector TD; Laakso M; Strom TM; Bell GI; Blangero J; Duggirala R; Tai ES; McVean G; Hanis CL; Wilson JG; Seielstad M; Frayling TM; Meigs JB; Cox NJ; Sladek R; Lander ES; Gabriel S; Burtt NP; Mohlke KL; Meitinger T; Groop L; Abecasis G; Florez JC; Scott LJ; Morris AP; Kang HM; Boehnke M; Altshuler D; McCarthy MI (2016)
      The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies have identified ...
    • Genome-wide association study identifies three novel loci for type 2 diabetes 

      Hara K; Fujita H; Johnson TA; Yamauchi T; Yasuda K; Horikoshi M; Peng C; Hu C; Ma RC; Imamura M; Iwata M; Tsunoda T; Morizono T; Shojima N; So WY; Leung TF; Kwan P; Zhang R; Wang J; Yu W; Maegawa H; Hirose H; DIAGRAM Consortium; Kaku K; Ito C; Watada H; Tanaka Y; Tobe K; Kashiwagi A; Kawamori R; Jia W; Chan JC; Teo YY; Shyong TE; Kamatani N; Kubo M; Maeda S; Kadowaki T (2014)
      Although over 60 loci for type 2 diabetes (T2D) have been identified, there still remains a large genetic component to be clarified. To explore unidentified loci for T2D, we performed a genome-wide association study (GWAS) ...
    • Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians 

      Cho YS; Chen CH; Hu C; Long J; Ong RT; Sim X; Takeuchi F; Wu Y; Go MJ; Yamauchi T; Chang YC; Kwak SH; Ma RC; Yamamoto K; Adair LS; Aung T; Cai Q; Chang LC; Chen YT; Gao Y; Hu FB; Kim HL; Kim S; Kim YJ; Lee JJ; Lee NR; Li Y; Liu JJ; Lu W; Nakamura J; Nakashima E; Ng DP; Tay WT; Tsai FJ; Wong TY; Yokota M; Zheng W; Zhang R; Wang C; So WY; Ohnaka K; Ikegami H; Hara K; Cho YM; Cho NH; Chang TJ; Bao Y; Hedman ÅK; Morris AP; McCarthy MI; DIAGRAM Consortium; MuTHER Consortium; Takayanagi R; Park KS; Jia W; Chuang LM; Chan JC; Maeda S; Kadowaki T; Lee JY; Wu JY; Teo YY; Tai ES; Shu XO; Mohlke KL; Kato N; Han BG; Seielstad M (2011)
      We conducted a three-stage genetic study to identify susceptibility loci for type 2 diabetes (T2D) in east Asian populations. We followed our stage 1 meta-analysis of eight T2D genome-wide association studies (6,952 cases ...