Now showing items 1-2 of 2

    • Evidence of inbreeding depression on human height 

      McQuillan R; Eklund N; Pirastu N; Kuningas M; McEvoy BP; Esko T; Corre T; Davies G; Kaakinen M; Lyytikäinen LP; Kristiansson K; Havulinna AS; Gögele M; Vitart V; Tenesa A; Aulchenko Y; Hayward C; Johansson A; Boban M; Ulivi S; Robino A; Boraska V; Igl W; Wild SH; Zgaga L; Amin N; Theodoratou E; Polašek O; Girotto G; Lopez LM; Sala C; Lahti J; Laatikainen T; Prokopenko I; Kals M; Viikari J; Yang J; Pouta A; Estrada K; Hofman A; Freimer N; Martin NG; Kähönen M; Milani L; Heliövaara M; Vartiainen E; Räikkönen K; Masciullo C; Starr JM; Hicks AA; Esposito L; Kolčić I; Farrington SM; Oostra B; Zemunik T; Campbell H; Kirin M; Pehlic M; Faletra F; Porteous D; Pistis G; Widén E; Salomaa V; Koskinen S; Fischer K; Lehtimäki T; Heath A; McCarthy MI; Rivadeneira F; Montgomery GW; Tiemeier H; Hartikainen AL; Madden PA; D'Adamo P; Hastie ND; Gyllensten U; Wright AF; van Duijn CM; Dunlop M; Rudan I; Gasparini P; Pramstaller PP; Deary IJ; Toniolo D; Eriksson JG; Jula A; Raitakari OT; Metspalu A; Perola M; Järvelin MR; Uitterlinden A; Visscher PM; Wilson JF; ROHgen Consortium (2012)
      Stature is a classical and highly heritable complex trait, with 80%-90% of variation explained by genetic factors. In recent years, genome-wide association studies (GWAS) have successfully identified many common additive ...
    • Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels 

      Kilpeläinen TO; Carli JF; Skowronski AA; Sun Q; Kriebel J; Feitosa MF; Hedman ÅK; Drong AW; Hayes JE; Zhao J; Pers TH; Schick U; Grarup N; Kutalik Z; Trompet S; Mangino M; Kristiansson K; Beekman M; Lyytikäinen LP; Eriksson J; Henneman P; Lahti J; Tanaka T; Luan J; Del Greco M F; Pasko D; Renström F; Willems SM; Mahajan A; Rose LM; Guo X; Liu Y; Kleber ME; Pérusse L; Gaunt T; Ahluwalia TS; Ju Sung Y; Ramos YF; Amin N; Amuzu A; Barroso I; Bellis C; Blangero J; Buckley BM; Böhringer S; I Chen YD; de Craen AJ; Crosslin DR; Dale CE; Dastani Z; Day FR; Deelen J; Delgado GE; Demirkan A; Finucane FM; Ford I; Garcia ME; Gieger C; Gustafsson S; Hallmans G; Hankinson SE; Havulinna AS; Herder C; Hernandez D; Hicks AA; Hunter DJ; Illig T; Ingelsson E; Ioan-Facsinay A; Jansson JO; Jenny NS; Jørgensen ME; Jørgensen T; Karlsson M; Koenig W; Kraft P; Kwekkeboom J; Laatikainen T; Ladwig KH; LeDuc CA; Lowe G; Lu Y; Marques-Vidal P; Meisinger C; Menni C; Morris AP; Myers RH; Männistö S; Nalls MA; Paternoster L; Peters A; Pradhan AD; Rankinen T; Rasmussen-Torvik LJ; Rathmann W; Rice TK; Brent Richards J; Ridker PM; Sattar N; Savage DB; Söderberg S; Timpson NJ; Vandenput L; van Heemst D; Uh HW; Vohl MC; Walker M; Wichmann HE; Widén E; Wood AR; Yao J; Zeller T; Zhang Y; Meulenbelt I; Kloppenburg M; Astrup A; Sørensen TI; Sarzynski MA; Rao DC; Jousilahti P; Vartiainen E; Hofman A; Rivadeneira F; Uitterlinden AG; Kajantie E; Osmond C; Palotie A; Eriksson JG; Heliövaara M; Knekt PB; Koskinen S; Jula A; Perola M; Huupponen RK; Viikari JS; Kähönen M; Lehtimäki T; Raitakari OT; Mellström D; Lorentzon M; Casas JP; Bandinelli S; März W; Isaacs A; van Dijk KW; van Duijn CM; Harris TB; Bouchard C; Allison MA; Chasman DI; Ohlsson C; Lind L; Scott RA; Langenberg C; Wareham NJ; Ferrucci L; Frayling TM; Pramstaller PP; Borecki IB; Waterworth DM; Bergmann S; Waeber G; Vollenweider P; Vestergaard H; Hansen T; Pedersen O; Hu FB; Eline Slagboom P; Grallert H; Spector TD; Jukema JW; Klein RJ; Schadt EE; Franks PW; Lindgren CM; Leibel RL; Loos RJ (2016)
      Leptin is an adipocyte-secreted hormone, the circulating levels of which correlate closely with overall adiposity. Although rare mutations in the leptin (LEP) gene are well known to cause leptin deficiency and severe ...