Now showing items 1-6 of 6

    • Evidence of inbreeding depression on human height 

      McQuillan R; Eklund N; Pirastu N; Kuningas M; McEvoy BP; Esko T; Corre T; Davies G; Kaakinen M; Lyytikäinen LP; Kristiansson K; Havulinna AS; Gögele M; Vitart V; Tenesa A; Aulchenko Y; Hayward C; Johansson A; Boban M; Ulivi S; Robino A; Boraska V; Igl W; Wild SH; Zgaga L; Amin N; Theodoratou E; Polašek O; Girotto G; Lopez LM; Sala C; Lahti J; Laatikainen T; Prokopenko I; Kals M; Viikari J; Yang J; Pouta A; Estrada K; Hofman A; Freimer N; Martin NG; Kähönen M; Milani L; Heliövaara M; Vartiainen E; Räikkönen K; Masciullo C; Starr JM; Hicks AA; Esposito L; Kolčić I; Farrington SM; Oostra B; Zemunik T; Campbell H; Kirin M; Pehlic M; Faletra F; Porteous D; Pistis G; Widén E; Salomaa V; Koskinen S; Fischer K; Lehtimäki T; Heath A; McCarthy MI; Rivadeneira F; Montgomery GW; Tiemeier H; Hartikainen AL; Madden PA; D'Adamo P; Hastie ND; Gyllensten U; Wright AF; van Duijn CM; Dunlop M; Rudan I; Gasparini P; Pramstaller PP; Deary IJ; Toniolo D; Eriksson JG; Jula A; Raitakari OT; Metspalu A; Perola M; Järvelin MR; Uitterlinden A; Visscher PM; Wilson JF; ROHgen Consortium (2012)
      Stature is a classical and highly heritable complex trait, with 80%-90% of variation explained by genetic factors. In recent years, genome-wide association studies (GWAS) have successfully identified many common additive ...
    • Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function 

      Pattaro C; Teumer A; Gorski M; Chu AY; Li M; Mijatovic V; Garnaas M; Tin A; Sorice R; Li Y; Taliun D; Olden M; Foster M; Yang Q; Chen MH; Pers TH; Johnson AD; Ko YA; Fuchsberger C; Tayo B; Nalls M; Feitosa MF; Isaacs A; Dehghan A; D'Adamo P; Adeyemo A; Dieffenbach AK; Zonderman AB; ; Nolte IM; van der Most PJ; Wright AF; Shuldiner AR; Morrison AC; Hofman A; Smith AV; Dreisbach AW; Franke A; Uitterlinden AG; Metspalu A; Tonjes A; Lupo A; Robino A; Johansson A; Demirkan A; Kollerits B; Freedman BI; Ponte B; Oostra BA; Paulweber B; Krämer BK (2016)
      Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular ...
    • Genome-wide association analyses identify 18 new loci associated with serum urate concentrations 

      Köttgen A; Albrecht E; Teumer A; Vitart V; Krumsiek J; Hundertmark C; Pistis G; Ruggiero D; O'Seaghdha CM; Haller T; Yang Q; Tanaka T; Johnson AD; Kutalik Z; Smith AV; Shi J; Struchalin M; Middelberg RP; Brown MJ; Gaffo AL; Pirastu N; Li G; Hayward C; Zemunik T; Huffman J; Yengo L; Zhao JH; Demirkan A; Feitosa MF; Liu X; Malerba G; Lopez LM; van der Harst P; Li X; Kleber ME; Hicks AA; Nolte IM; Johansson A; Murgia F; Wild SH; Bakker SJ; Peden JF; Dehghan A; Steri M; Tenesa A; Lagou V; Salo P; Mangino M; Rose LM; Lehtimäki T; Woodward OM; Okada Y; Tin A; Müller C; Oldmeadow C; Putku M; Czamara D; Kraft P; Frogheri L; Thun GA; Grotevendt A; Gislason GK; Harris TB; Launer LJ; McArdle P; Shuldiner AR; Boerwinkle E; Coresh J; Schmidt H; Schallert M; Martin NG; Montgomery GW; Kubo M; Nakamura Y; Munroe PB; Samani NJ; Jacobs DR; Liu K; D'Adamo P; Ulivi S; Rotter JI; Psaty BM; Vollenweider P; Waeber G; Campbell S; Devuyst O; Navarro P; Kolcic I; Hastie N; Balkau B; Froguel P; Esko T; Salumets A; Khaw KT; Langenberg C; Wareham NJ; Isaacs A; Kraja A; Zhang Q; Wild PS; Scott RJ; Holliday EG; Org E; Viigimaa M; Bandinelli S; Metter JE; Lupo A; Trabetti E; Sorice R; Döring A; Lattka E; Strauch K; Theis F; Waldenberger M; Wichmann HE; Davies G; Gow AJ; Bruinenberg M; LifeLines Cohort Study; Stolk RP; Kooner JS; Zhang W; Winkelmann BR; Boehm BO; Lucae S; Penninx BW; Smit JH; Curhan G; Mudgal P; Plenge RM; Portas L; Persico I; Kirin M; Wilson JF; Mateo Leach I; van Gilst WH; Goel A; Ongen H; Hofman A; Rivadeneira F; Uitterlinden AG; Imboden M; von Eckardstein A; Cucca F; Nagaraja R; Piras MG; Nauck M; Schurmann C; Budde K; Ernst F; Farrington SM; Theodoratou E; Prokopenko I; Stumvoll M; Jula A; Perola M; Salomaa V; Shin SY; Spector TD; Sala C; Ridker PM; Kähönen M; Viikari J; Hengstenberg C; Nelson CP; CARDIoGRAM Consortium; DIAGRAM Consortium; ICBP Consortium; MAGIC Consortium; Meschia JF; Nalls MA; Sharma P; Singleton AB; Kamatani N; Zeller T; Burnier M; Attia J; Laan M; Klopp N; Hillege HL; Kloiber S; Choi H; Pirastu M; Tore S; Probst-Hensch NM; Völzke H; Gudnason V; Parsa A; Schmidt R; Whitfield JB; Fornage M; Gasparini P; Siscovick DS; Polašek O; Campbell H; Rudan I; Bouatia-Naji N; Metspalu A; Loos RJ; van Duijn CM; Borecki IB; Ferrucci L; Gambaro G; Deary IJ; Wolffenbuttel BH; Chambers JC; März W; Pramstaller PP; Snieder H; Gyllensten U; Wright AF; Navis G; Watkins H; Witteman JC; Sanna S; Schipf S; Dunlop MG; Tönjes A; Ripatti S; Soranzo N; Toniolo D; Chasman DI; Raitakari O; Kao WH; Ciullo M; Fox CS; Caulfield M; Bochud M; Gieger C (2013)
      Elevated serum urate concentrations can cause gout, a prevalent and painful inflammatory arthritis. By combining data from >140,000 individuals of European ancestry within the Global Urate Genetics Consortium (GUGC), we ...
    • Influence of age, sex and ethnicity on platelet count in five Italian geographic isolates: mild thrombocytopenia may be physiological 

      Biino G; Gasparini P; D'Adamo P; Ciullo M; Nutile T; Toniolo D; Sala C; Minelli C; Gögele M; Balduini CL (2012)
    • Modulation of genetic associations with serum urate levels by body-mass-index in humans 

      Huffman JE; Albrecht E; Teumer A; Mangino M; Kapur K; Johnson T; Kutalik Z; Pirastu N; Pistis G; Lopez LM; Haller T; Salo P; Goel A; Li M; Tanaka T; Dehghan A; Ruggiero D; Malerba G; Smith AV; Nolte IM; Portas L; Phipps-Green A; Boteva L; Navarro P; Johansson A; Hicks AA; Polasek O; Esko T; Peden JF; Harris SE; Murgia F; Wild SH; Tenesa A; Tin A; Mihailov E; Grotevendt A; Gislason GK; Coresh J; D'Adamo P; Ulivi S; Vollenweider P; Waeber G; Campbell S; Kolcic I; Fisher K; Viigimaa M; Metter JE; Masciullo C; Trabetti E; Bombieri C; Sorice R; Döring A; Reischl E; Strauch K; Hofman A; Uitterlinden AG; Waldenberger M; Wichmann HE; Davies G; Gow AJ; Dalbeth N; Stamp L; Smit JH; Kirin M; Nagaraja R; Nauck M; Schurmann C; Budde K; Farrington SM; Theodoratou E; Jula A; Salomaa V; Sala C; Hengstenberg C; Burnier M; Mägi R; Klopp N; Kloiber S; Schipf S; Ripatti S; Cabras S; Soranzo N; Homuth G; Nutile T; Munroe PB; Hastie N; Campbell H; Rudan I; Cabrera C; Haley C; Franco OH; Merriman TR; Gudnason V; Pirastu M; Penninx BW; Snieder H; Metspalu A; Ciullo M; Pramstaller PP; van Duijn CM; Ferrucci L; Gambaro G; Deary IJ; Dunlop MG; Wilson JF; Gasparini P; Gyllensten U; Spector TD; Wright AF; Hayward C; Watkins H; Perola M; Bochud M; Kao WH; Caulfield M; Toniolo D; Völzke H; Gieger C; Köttgen A; Vitart V (2015)
      We tested for interactions between body mass index (BMI) and common genetic variants affecting serum urate levels, genome-wide, in up to 42569 participants. Both stratified genome-wide association (GWAS) analyses, in lean, ...
    • New gene functions in megakaryopoiesis and platelet formation 

      Gieger C; Radhakrishnan A; Cvejic A; Tang W; Porcu E; Pistis G; Serbanovic-Canic J; Elling U; Goodall AH; Labrune Y; Lopez LM; Mägi R; Meacham S; Okada Y; Pirastu N; Sorice R; Teumer A; Voss K; Zhang W; Ramirez-Solis R; Bis JC; Ellinghaus D; Gögele M; Hottenga JJ; Langenberg C; Kovacs P; O'Reilly PF; Shin SY; Esko T; Hartiala J; Kanoni S; Murgia F; Parsa A; Stephens J; van der Harst P; Ellen van der Schoot C; Allayee H; Attwood A; Balkau B; Bastardot F; Basu S; Baumeister SE; Biino G; Bomba L; Bonnefond A; Cambien F; Chambers JC; Cucca F; D'Adamo P; Davies G; de Boer RA; de Geus EJ; Döring A; Elliott P; Erdmann J; Evans DM; Falchi M; Feng W; Folsom AR; Frazer IH; Gibson QD; Glazer NL; Hammond C; Hartikainen AL; Heckbert SR; Hengstenberg C; Hersch M; Illig T; Loos RJ; Jolley J; Khaw KT; Kühnel B; Kyrtsonis MC; Lagou V; Lloyd-Jones H; Lumley T; Mangino M; Maschio A; Mateo Leach I; McKnight B; Memari Y; Mitchell BD; Montgomery GW; Nakamura Y; Nauck M; Navis G; Nöthlings U; Nolte IM; Porteous DJ; Pouta A; Pramstaller PP; Pullat J; Ring SM; Rotter JI; Ruggiero D; Ruokonen A; Sala C; Samani NJ; Sambrook J; Schlessinger D; Schreiber S; Schunkert H; Scott J; Smith NL; Snieder H; Starr JM; Stumvoll M; Takahashi A; Tang WH; Taylor K; Tenesa A; Lay Thein S; Tönjes A; Uda M; Ulivi S; van Veldhuisen DJ; Visscher PM; Völker U; Wichmann HE; Wiggins KL; Willemsen G; Yang TP; Hua Zhao J; Zitting P; Bradley JR; Dedoussis GV; Gasparini P; Hazen SL; Metspalu A; Pirastu M; Shuldiner AR; Joost van Pelt L; Zwaginga JJ; Boomsma DI; Deary IJ; Franke A; Froguel P; Ganesh SK; Jarvelin MR; Martin NG; Meisinger C; Psaty BM; Spector TD; Wareham NJ; Akkerman JW; Ciullo M; Deloukas P; Greinacher A; Jupe S; Kamatani N; Khadake J; Kooner JS; Penninger J; Prokopenko I; Stemple D; Toniolo D; Wernisch L; Sanna S; Hicks AA; Rendon A; Ferreira MA; Ouwehand WH; Soranzo N (2011)
      Platelets are the second most abundant cell type in blood and are essential for maintaining haemostasis. Their count and volume are tightly controlled within narrow physiological ranges, but there is only limited understanding ...